MK-0557 is a highly selective, orally administered neuropeptide NPY5R antagonist, could limit weight regain after very-low-calorie diet (VLCD)-induced weight loss. Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target.
MedKoo Cat#: 525665
Name: MK-0557
CAS#: 328232-95-7
Chemical Formula: C22H19FN4O3
Exact Mass: 406.1441
Molecular Weight: 406.42
Elemental Analysis: C, 65.02; H, 4.71; F, 4.67; N, 13.79; O, 11.81
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| DMF | 5.0 | 12.30 | ||
| DMF:PBS (pH 7.2) (1:1) | 0.5 | 1.23 | ||
| DMSO | 101.5 | 249.91 |
The following data is based on the product molecular weight 406.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
