MedKoo Cat#: 524848 | Name: CP-472555

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-472555 is a selective, nonsteroidal glucocorticoid receptor antagonist, with anti-GR and anti-obesity activity in animal models.

Chemical Structure

CP-472555
CP-472555
CAS#305821-96-9

Theoretical Analysis

MedKoo Cat#: 524848

Name: CP-472555

CAS#: 305821-96-9

Chemical Formula: C31H32N2O2

Exact Mass: 464.2464

Molecular Weight: 464.60

Elemental Analysis: C, 80.14; H, 6.94; N, 6.03; O, 6.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CP-472555; CP 472555; CP472555; UNII-6T0KV7024R.
IUPAC/Chemical Name
2-Phenanthrenecarboxamide, 4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-4b-(phenylmethyl)-7-(1-propyn-1-yl)-N-(3-pyridinylmethyl)-, (4bS,7R,8aR)-
InChi Key
SEOPOTXFVGEDGX-UPHHSBJESA-N
InChi Code
InChI=1S/C31H32N2O2/c1-2-14-30(35)15-16-31(19-23-7-4-3-5-8-23)27(20-30)12-10-25-18-26(11-13-28(25)31)29(34)33-22-24-9-6-17-32-21-24/h3-9,11,13,17-18,21,27,35H,10,12,15-16,19-20,22H2,1H3,(H,33,34)/t27-,30-,31+/m1/s1
SMILES Code
CC#C[C@]1(CC[C@]2(c3ccc(cc3CC[C@@H]2C1)C(=O)NCc4cccnc4)Cc5ccccc5)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 464.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Briski KP, Kale AY, Vavaiya KV. Impact of recurring intermediate insulin-induced hypoglycemia on hypothalamic paraventricular corticotropin-releasing hormone, oxytocin, vasopressin and glucokinase gene profiles: role of type II glucocorticoid receptors. Exp Brain Res. 2009 Jun;195(4):499-507. doi: 10.1007/s00221-009-1787-4. Epub 2009 May 6. PubMed PMID: 19418044. 2: Kale AY, Paranjape SA, Briski KP. Type II glucocorticoid receptor involvement in habituated activation of lateral hypothalamic area orexin-A-immunopositive neurons during recurring insulin-induced hypoglycemia. Neurosci Res. 2006 Nov;56(3):309-13. Epub 2006 Sep 25. PubMed PMID: 16997409. 3: Kale AY, Vavaiya KV, Briski KP. Effects of acute and chronic insulin-induced hypoglycemia on type II glucocorticoid receptor (GR) gene expression in characterized CNS metabolic loci. Brain Res Bull. 2006 Jul 31;70(3):240-4. Epub 2006 Jun 6. PubMed PMID: 16861109. 4: Kale AY, Paranjape SA, Briski KP. Site-specific habituation of insulin-induced hypoglycemic induction of fos immunoreactivity in glucocorticoid receptor: immunopositive neurons in the male rat brain. Exp Brain Res. 2007 Jan;176(2):260-6. PubMed PMID: 16850320. 5: Kale AY, Paranjape SA, Briski KP. I.c.v. administration of the nonsteroidal glucocorticoid receptor antagonist, CP-472555, prevents exacerbated hypoglycemia during repeated insulin administration. Neuroscience. 2006 Jun 30;140(2):555-65. Epub 2006 Apr 19. PubMed PMID: 16626867.