CP-432 | CP-734432 | CAS#431990-08-8

MedKoo Cat#: 524839 | Name: CP-432

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CP-432, also known as CP-734432, is an EP4 prostaglandin agonist and is potential useful for the treatment of glaucoma and ocular hypertension.

Chemical Structure

CP-432

CAS#431990-08-8

Theoretical Analysis

MedKoo Cat#: 524839

Name: CP-432

CAS#: 431990-08-8

Chemical Formula: C23H26F3NO4S

Exact Mass: 469.1535

Molecular Weight: 469.52

Elemental Analysis: C, 58.84; H, 5.58; F, 12.14; N, 2.98; O, 13.63; S, 6.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

CP-432; CP 432; CP432; CP-734432; CP 734432; CP734432.

IUPAC/Chemical Name

2-Thiophenecarboxylic acid, 5-(3-((2S)-2-((3R)-3-hydroxy-4-(3-(trifluoromethyl)phenyl)butyl)-5-oxo-1-pyrrolidinyl)propyl)-

InChi Key

JYZXGURJKNAFPT-ZWKOTPCHSA-N

InChi Code

InChI=1S/C23H26F3NO4S/c24-23(25,26)16-4-1-3-15(13-16)14-18(28)8-6-17-7-11-21(29)27(17)12-2-5-19-9-10-20(32-19)22(30)31/h1,3-4,9-10,13,17-18,28H,2,5-8,11-12,14H2,(H,30,31)/t17-,18+/m0/s1

SMILES Code

c1cc(cc(c1)C(F)(F)F)C[C@@H](CC[C@H]2CCC(=O)N2CCCc3ccc(s3)C(=O)O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 469.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hu KZ, Ma J, Qiu S, Zheng X, Huang PQ. SmI2-mediated intermolecular coupling of γ-lactam N-α-radicals with activated alkenes: asymmetric synthesis of 11-hydroxylated analogues of the lead compounds CP-734432 and PF-04475270. J Org Chem. 2013 Mar 1;78(5):1790-801. doi: 10.1021/jo301277n. Epub 2012 Aug 14. PubMed PMID: 22853560. 2: Luu KT, Zhang EY, Prasanna G, Xiang C, Anderson S, Fortner J, Vicini P. Pharmacokinetic-pharmacodynamic and response sensitization modeling of the intraocular pressure-lowering effect of the EP4 Agonist 5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3-(trifluoromethyl)phenyl]butyl}-5-oxopyrrolidin- 1-yl]propyl}thiophene-2-carboxylate (PF-04475270). J Pharmacol Exp Ther. 2009 Nov;331(2):627-35. doi: 10.1124/jpet.109.157800. Epub 2009 Aug 18. PubMed PMID: 19690190. 3: Prasanna G, Fortner J, Xiang C, Zhang E, Carreiro S, Anderson S, Sartnurak S, Wu G, Gukasyan H, Niesman M, Nair S, Rui E, Lafontaine J, Almaden CD, Wells P, Krauss A. Ocular pharmacokinetics and hypotensive activity of PF-04475270, an EP4 prostaglandin agonist in preclinical models. Exp Eye Res. 2009 Nov;89(5):608-17. doi: 10.1016/j.exer.2009.05.002. Epub 2009 May 13. PubMed PMID: 19445930.