MK-0359, also known as L454560, is a selective and potent oral PDE4 inhibitor for the treatment of chronic asthma. Over a 14-day treatment period, the oral PDE4 inhibitor MK-0359 improved lower airway function, symptoms and rescue medication use in chronic asthma, although at the expense of gastrointestinal adverse experiences.
MedKoo Cat#: 525662
Name: MK-0359
CAS#: 346629-30-9
Chemical Formula: C31H29N3O5S2
Exact Mass: 587.1549
Molecular Weight: 587.71
Elemental Analysis: C, 63.35; H, 4.97; N, 7.15; O, 13.61; S, 10.91
The following data is based on the product molecular weight 587.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
