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MedKoo Cat#: 525650 | Name: MK436

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK436 is a therapeutic agent and an anti-protozoal drug. It is found to be effective against Trypanosoma cruzi infections.

Chemical Structure

MK436
MK436
CAS#33450-08-7

Theoretical Analysis

MedKoo Cat#: 525650

Name: MK436

CAS#: 33450-08-7

Chemical Formula: C11H14N4O3

Exact Mass: 250.1066

Molecular Weight: 250.25

Elemental Analysis: C, 52.79; H, 5.64; N, 22.39; O, 19.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MK-436; MK 436; MK436
IUPAC/Chemical Name
3-(1-methyl-5-nitro-1H-imidazol-2-yl)-3a,4,5,6,7,7a-hexahydrobenzo[d]isoxazole
InChi Key
SPUUHYKZDFCYGW-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H14N4O3/c1-14-9(15(16)17)6-12-11(14)10-7-4-2-3-5-8(7)18-13-10/h6-8H,2-5H2,1H3
SMILES Code
O=[N+](C1=CN=C(C2=NOC3CCCCC23)N1C)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 250.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jennings FW, Atouguia JM, Murray M. Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436. Trop Med Int Health. 1996 Oct;1(5):590-8. PubMed PMID: 8911443. 2: Jennings FW. Chemotherapy of CNS-trypanosomiasis: combination chemotherapy with a 5-nitroimidazole (MK 436), an arsenical (Cymelarsan) and suramin. Trop Med Parasitol. 1991 Sep;42(3):157-60. PubMed PMID: 1801135. 3: Andrade SG, Silva RC, Santiago CM. Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole. Bull World Health Organ. 1989;67(5):509-14. PubMed PMID: 2515007; PubMed Central PMCID: PMC2491297. 4: Andrade SG, Silva RC, Santiago CM, Freitas LA. Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study. Bull World Health Organ. 1987;65(5):625-33. PubMed PMID: 3123082; PubMed Central PMCID: PMC2491062. 5: Murray PK, Habbersett MC, Meurer RD. Trypanosoma cruzi: efficacy of the 2-substituted, 5-nitroimidazoles, MK-436 and L634,549, in tissue culture and mice. Am J Trop Med Hyg. 1983 Nov;32(6):1242-50. PubMed PMID: 6418014.