Synonym
PIK-293; PIK 293; PIK293.
IUPAC/Chemical Name
2-((4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one
InChi Key
KQDBVHKNIYROHU-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H19N7O/c1-13-6-3-4-9-17(13)29-18(27-16-8-5-7-14(2)19(16)22(29)30)11-28-21-15(10-26-28)20(23)24-12-25-21/h3-10,12H,11H2,1-2H3,(H2,23,24,25)
SMILES Code
O=C1N(C2=CC=CC=C2C)C(CN3N=CC4=C(N)N=CN=C43)=NC5=C1C(C)=CC=C5
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
PIK-293, an analog of IC87114, is a PI3K inhibitor, with IC50 values of 0.24 μM, 10 μM, 25 μM and 100 μM for p110δ, p110β, p110γ and p110α.
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| DMF |
30.0 |
75.48 |
|
| DMSO |
53.3 |
134.19 |
|
| DMSO:PBS (pH 7.2) (1:6) |
0.1 |
0.35 |
|
| Ethanol |
0.3 |
0.63 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
397.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Zhu, J., Li, K., Yu, L., Chen, Y., Cai, Y., Jin, J., & Hou, T. (2021). Targeting phosphatidylinositol 3‐kinase gamma (PI3Kγ): Discovery and development of its selective inhibitors. Medicinal research reviews, 41(3), 1599-1621.
Cmiljanović, N. (2011). Development of novel, potent and selective small molecular weight PI3K/mTOR inhibitors for the treatment of cancer (Doctoral dissertation, University_of_Basel).
Chandra Joshi, M., Kumar, K., & Kumar, V. (2014). Potent phosphatidylinositol 3-kinase inhibitors and their biology. Current drug discovery technologies, 11(2), 113-126.
