Synonym
SHR3824; SHR-3824; SHR 3824; Henagliflozin
IUPAC/Chemical Name
(1R,2S,3S,4R,5R)-5-(4-chloro-3-(4-ethoxy-3-fluorobenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triol
InChi Key
HYTPDMFFHVZBOR-VNXMGFANSA-N
InChi Code
InChI=1S/C22H24ClFO7/c1-2-29-17-6-3-12(8-16(17)24)7-13-9-14(4-5-15(13)23)22-20(28)18(26)19(27)21(10-25,31-22)11-30-22/h3-6,8-9,18-20,25-28H,2,7,10-11H2,1H3/t18-,19-,20+,21+,22+/m0/s1
SMILES Code
O[C@@H]1[C@@](O2)(CO)CO[C@@]2(C3=CC=C(Cl)C(CC4=CC=C(OCC)C(F)=C4)=C3)[C@H](O)[C@H]1O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
454.88
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yong X, Wen A, Liu X, Liu H, Liu YP, Li N, Hu T, Chen Y, Wang M, Wang L, Dai
X, Huang J, Li J, Shen H. Pharmacokinetics and Pharmacodynamics of Henagliflozin,
a Sodium Glucose Co-Transporter 2 Inhibitor, in Chinese Patients with Type 2
Diabetes Mellitus. Clin Drug Investig. 2016 Mar;36(3):195-202. doi:
10.1007/s40261-015-0366-7. PubMed PMID: 26692004.
2: Wang L, Wu C, Shen L, Liu H, Chen Y, Liu F, Wang Y, Yang J. Evaluation of
drug-drug interaction between henagliflozin, a novel sodium-glucose
co-transporter 2 inhibitor, and metformin in healthy Chinese males. Xenobiotica.
2016 Aug;46(8):703-8. doi: 10.3109/00498254.2015.1113576. Epub 2015 Nov 26.
PubMed PMID: 26608671.
3: Yan PK, Zhang LN, Feng Y, Qu H, Qin L, Zhang LS, Leng Y. SHR3824, a novel
selective inhibitor of renal sodium glucose cotransporter 2, exhibits
antidiabetic efficacy in rodent models. Acta Pharmacol Sin. 2014
May;35(5):613-24. doi: 10.1038/aps.2013.196. PubMed PMID: 24786232; PubMed
Central PMCID: PMC4814034.
