MK 0434 | CAS#134067-56-4 | Antagonist-Inhibitor

MedKoo Cat#: 525636 | Name: MK 0434

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK 0434 is a steroid 5 alpha-reductase inhibitor and a hormone antagonist. MK-0434 is associated with a significant reduction in dihydrotestosterone.

Chemical Structure

MK 0434

CAS#134067-56-4

Theoretical Analysis

MedKoo Cat#: 525636

Name: MK 0434

CAS#: 134067-56-4

Chemical Formula: C25H31NO2

Exact Mass: 377.2355

Molecular Weight: 377.53

Elemental Analysis: C, 79.54; H, 8.28; N, 3.71; O, 8.48

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

MK0434; MK-0434; MK 0434; MK-434; MK434; MK 434

IUPAC/Chemical Name

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-7-benzoyl-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-2H-indeno[5,4-f]quinolin-2-one

InChi Key

ZYTQEOWFSVTRLX-QKONGSNMSA-N

InChi Code

InChI=1S/C25H31NO2/c1-24-14-12-19-17(8-11-21-25(19,2)15-13-22(27)26-21)18(24)9-10-20(24)23(28)16-6-4-3-5-7-16/h3-7,13,15,17-21H,8-12,14H2,1-2H3,(H,26,27)/t17-,18-,19-,20+,21+,24-,25+/m0/s1

SMILES Code

C[C@@]12[C@@H](C(C3=CC=CC=C3)=O)CC[C@@]1([H])[C@]4([H])CC[C@@]5([H])NC(C=C[C@]5(C)[C@@]4([H])CC2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 377.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Van Hecken A, Depré M, Schwartz JI, Tjandramaga TB, Winchell GA, De Lepeleire I, Ng J, De Schepper PJ. Plasma concentrations and effect on testosterone metabolism after single doses of MK-0434, a steroid 5 alpha-reductase inhibitor, in healthy subjects. Eur J Clin Pharmacol. 1994;46(2):123-6. PubMed PMID: 8039530.