MedKoo Cat#: 524723 | Name: CI-1002

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CI-1002 is a novel anticholinesterase and muscarinic antagonist. The combined effect of AChE inhibition and muscarinic antagonism distinguishes PD 142676 from other anticholinesterases, and may be useful in treating the cognitive dysfunction of AD and produce fewer peripheral side effects.

Chemical Structure

CI-1002
CI-1002
CAS#149028-28-4 (CI-1002)

Theoretical Analysis

MedKoo Cat#: 524723

Name: CI-1002

CAS#: 149028-28-4 (CI-1002)

Chemical Formula: C13H14Cl2N2

Exact Mass: 268.0534

Molecular Weight: 269.17

Elemental Analysis: C, 58.01; H, 5.24; Cl, 26.34; N, 10.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CI-1002; CI 1002; CI1002; PD-142676; UNII-7U374ZW3YB.
IUPAC/Chemical Name
1,3-dichloro-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline
InChi Key
WTPSHLVHJOJDIF-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H14Cl2N2/c14-9-6-11(15)10-8-17-5-3-1-2-4-13(17)16-12(10)7-9/h6-7H,1-5,8H2
SMILES Code
c1c(cc(c2c1N=C3CCCCCN3C2)Cl)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related: 149028-28-4 (CI-1002) 149062-75-9 (CI-1002 hydrochloride)

Preparing Stock Solutions

The following data is based on the product molecular weight 269.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Emmerling MR, Gregor VE, Schwarz RD, Scholten JD, Callahan MJ, Lee C, Moore CJ, Raby C, Lipinski WJ, Davis RE. PD 142676 (CI 1002), a novel anticholinesterase and muscarinic antagonist. Mol Neurobiol. 1994 Aug-Dec;9(1-3):93-106. PubMed PMID: 7888109. 2: Ros E, Aleu J, Marsal J, Solsona C. Effects of CI-1002 and CI-1017 on spontaneous synaptic activity and on the nicotinic acetylcholine receptor of Torpedo electric organ. Eur J Pharmacol. 2000 Feb 25;390(1-2):7-13. PubMed PMID: 10708701.