Synonym
CI 951; CI-951; CI951.
IUPAC/Chemical Name
1,6-Naphthyridine-3-carboxylic acid, 1,4-dihydro-2-methyl-5-(1-methylethoxy)-4-(2-(trifluoromethyl)phenyl)-, ethyl ester
InChi Key
XVXQOAYCEUDQTQ-SFHVURJKSA-N
InChi Code
InChI=1S/C22H23F3N2O3/c1-5-29-21(28)17-13(4)27-16-10-11-26-20(30-12(2)3)19(16)18(17)14-8-6-7-9-15(14)22(23,24)25/h6-12,18,27H,5H2,1-4H3/t18-/m0/s1
SMILES Code
N1C(=C([C@@H](c2c(nccc12)OC(C)C)c1c(cccc1)C(F)(F)F)C(=O)OCC)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
420.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Knight WA, Hart KW, Adeoye OM, Bonomo JB, Keegan SP, Ficker DM, Szaflarski JP, Privitera MD, Lindsell CJ. The incidence of seizures in patients undergoing therapeutic hypothermia after resuscitation from cardiac arrest. Epilepsy Res. 2013 Oct;106(3):396-402. doi: 10.1016/j.eplepsyres.2013.06.018. Epub 2013 Jul 29. PubMed PMID: 23906560; PubMed Central PMCID: PMC3961478.
2: Papadakaki M, Tzamalouka GS, Chatzifotiou S, Chliaoutakis J. Seeking for risk factors of Intimate Partner Violence (IPV) in a Greek national sample: the role of self-esteem. J Interpers Violence. 2009 May;24(5):732-50. doi: 10.1177/0886260508317181. Epub 2008 May 7. PubMed PMID: 18463309.
3: Koike K, Takayanagi I, Takiguchi S, Urita Y, Miyake N. Ca-blocking action of stereoisomers of CI-951, (+)-CI-951 (NC-1500) and (-)-CI-951 in the isolated muscle preparations. Gen Pharmacol. 1992 Mar;23(2):207-10. PubMed PMID: 1639233.
4: Pucilowski O, Rezvani AH, Janowsky DS. Suppression of alcohol and saccharin preference in rats by a novel Ca2+ channel inhibitor, Goe 5438. Psychopharmacology (Berl). 1992;107(2-3):447-52. PubMed PMID: 1615142.
5: Meyer FB, Anderson RE, Sundt TM Jr. The novel dihydronaphthyridine Ca2+ channel blocker CI-951 improves CBF, brain pHi, and EEG recovery in focal cerebral ischemia. J Cereb Blood Flow Metab. 1990 Jan;10(1):97-103. PubMed PMID: 2298840.
