Synonym
CI 943; CI-943; CI943.
IUPAC/Chemical Name
7,8-Dihydro-8-ethyl-1,3,5-trimethyl-1H-imidazo(1,2-c)pyrazolo(3,4-e)pyrimidine
InChi Key
YFAVYALYCRERKH-SECBINFHSA-N
InChi Code
InChI=1S/C12H17N5/c1-5-9-6-17-8(3)13-10-7(2)15-16(4)11(10)12(17)14-9/h9H,5-6H2,1-4H3/t9-/m1/s1
SMILES Code
C=1(N2C(c3c(N1)c(nn3C)C)=N[C@@H](C2)CC)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
231.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Liégeois JF, Bonaventure P, Delarge J, Damas J. Antipsychotics and neuropeptides: the atypical profile of CI-943 and its relationship to neurotensin. Neurosci Biobehav Rev. 1995 Winter;19(4):519-31. Review. Erratum in: Neurosci Biobehav Rev 1996 Summer;20(2):I. PubMed PMID: 8684714.
2: Henck JW, Petrere JA, Anderson JA. Developmental neurotoxicity of CI-943: a novel antipsychotic. Neurotoxicol Teratol. 1995 Jan-Feb;17(1):13-24. PubMed PMID: 7708015.
3: Levant B, Bissette G, Davis MD, Heffner TG, Nemeroff CB. Effects of CI-943, a potential antipsychotic drug, and haloperidol on regional brain neurotensin concentrations. Synapse. 1991 Nov;9(3):225-30. PubMed PMID: 1685600.
4: Krcmarik CS, Miceli JJ, Pachla LA. High-performance liquid chromatographic assay for a novel psychotropic drug (CI-943) in cynomolgus monkey plasma. J Chromatogr. 1989 Nov 24;496(2):493-9. PubMed PMID: 2613852.
5: Meltzer LT, Christoffersen CL, Heffner TG, Freeman AS, Chiodo LA. CI-943, a potential antipsychotic agent. III. Evaluation of effects on dopamine neuronal activity. J Pharmacol Exp Ther. 1989 Oct;251(1):123-30. PubMed PMID: 2571714.
6: Pugsley TA, Coughenour LL, Myers SL, Shih YH, Courtland GG, Berghoff W, Stewart SF. CI-943, a potential antipsychotic agent. II. Neurochemical effects. J Pharmacol Exp Ther. 1989 Oct;251(1):113-22. PubMed PMID: 2571713.
7: Heffner TG, Downs DA, Meltzer LT, Wiley JN, Williams AE. CI-943, a potential antipsychotic agent. I. Preclinical behavioral effects. J Pharmacol Exp Ther. 1989 Oct;251(1):105-12. PubMed PMID: 2571712.
8: DeWald HA, Beeson NW, Hershenson FM, Wise LD, Downs DA, Heffner TG, Coughenour LL, Pugsley TA. Synthesis and potential antipsychotic activity of 1H-imidazo[1,2-c]pyrazolo[3,4-e]pyrimidines. J Med Chem. 1988 Feb;31(2):454-61. PubMed PMID: 2892936.
