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MedKoo Cat#: 524655 | Name: CGP-59326

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CGP-59326 is an epidermal growth factor receptor (EGFR) antagonist in the use of anti-cancer research.

Chemical Structure

CGP-59326
CGP-59326
CAS#173458-56-5

Theoretical Analysis

MedKoo Cat#: 524655

Name: CGP-59326

CAS#: 173458-56-5

Chemical Formula: C14H13ClN4

Exact Mass: 272.0829

Molecular Weight: 272.73

Elemental Analysis: C, 61.65; H, 4.80; Cl, 13.00; N, 20.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CGP-59326; CGP 59326; CGP59326; TRX-13; UNII-YP9UZR062O.
IUPAC/Chemical Name
N-(3-chlorophenyl)-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
InChi Key
WXJDWBDGDSXEFA-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H13ClN4/c1-8-9(2)18-13-12(8)14(17-7-16-13)19-11-5-3-4-10(15)6-11/h3-7H,1-2H3,(H2,16,17,18,19)
SMILES Code
Cc1c([nH]c2c1c(ncn2)Nc3cccc(c3)Cl)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 272.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tørring N, Dagnaes-Hansen F, Sørensen BS, Nexø E, Hynes NE. ErbB1 and prostate cancer: ErbB1 activity is essential for androgen-induced proliferation and protection from the apoptotic effects of LY294002. Prostate. 2003 Jul 1;56(2):142-9. PubMed PMID: 12746839. 2: Motoyama AB, Hynes NE, Lane HA. The efficacy of ErbB receptor-targeted anticancer therapeutics is influenced by the availability of epidermal growth factor-related peptides. Cancer Res. 2002 Jun 1;62(11):3151-8. PubMed PMID: 12036928.