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MedKoo Cat#: 524619 | Name: Cgp 20309

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cgp 20309 is a thiocarbonylamides with high antifilarial activities.

Chemical Structure

Cgp 20309
Cgp 20309
CAS#122378-48-7

Theoretical Analysis

MedKoo Cat#: 524619

Name: Cgp 20309

CAS#: 122378-48-7

Chemical Formula: C18H26N4OS2

Exact Mass: 378.1548

Molecular Weight: 378.56

Elemental Analysis: C, 57.11; H, 6.92; N, 14.80; O, 4.23; S, 16.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Cgp 20309; Cgp20309; Cgp-20309.
IUPAC/Chemical Name
1-Piperazinecarbothioamide, N-(2-(1,1-dimethylethyl)-5-methoxy-6-benzothiazolyl)-4-methyl-
InChi Key
QQKZAUPDCVHWJD-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H26N4OS2/c1-18(2,3)16-19-13-10-14(23-5)12(11-15(13)25-16)20-17(24)22-8-6-21(4)7-9-22/h10-11H,6-9H2,1-5H3,(H,20,24)
SMILES Code
N1(CCN(CC1)C)C(Nc1c(cc2nc(sc2c1)C(C)(C)C)OC)=S
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 378.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zahner H, Franz M, Köhler P, Striebel HP. Antifilarial efficacy in vitro of 2-tert-butyl-benzothiazole derivatives on adult Litomosoides carinii. Arzneimittelforschung. 1991 Aug;41(8):821-7. PubMed PMID: 1781804. 2: Zahner H, Johri GN, Köhler P, Striebel HP, Franz M. In vitro effects of 2-tert-butyl-benzothiazole derivatives on microfilariae of Litomosoides carinii, Brugia malayi and Acanthocheilonema viteae. Arzneimittelforschung. 1991 Jul;41(7):764-8. PubMed PMID: 1772466. 3: More SJ, Copeman DB. The use of monoclonal antibody-based ELISAs to monitor the efficacy of drugs against male Onchocerca gibsoni in vitro. Trop Med Parasitol. 1991 Mar;42(1):21-4. PubMed PMID: 2052851. 4: More SJ, Copeman DB. The use of monoclonal antibody-based ELISAs to monitor chemotherapeutic effects in the bovine-Onchocerca gibsoni drug screen. Trop Med Parasitol. 1991 Mar;42(1):17-20. PubMed PMID: 2052850. 5: Zahner H, Striebel HP, Sänger I, Schütze HR. Antifilarial activities of benzazole derivatives. 3. Effects of benzothiazoles on third stage larvae and preadult worms of Acanthocheilonema viteae, Brugia malayi and B. pahangi in Mastomys natalensis. Trop Med Parasitol. 1990 Dec;41(4):407-10. PubMed PMID: 2075385. 6: Strote G. Studies on the activity of the Ciba Geigy compounds CGP 6140, 20376, 20309 and 21833 against third and fourth stage larvae of Onchocerca volvulus. Trop Med Parasitol. 1989 Mar;40(1):51-6. PubMed PMID: 2740728.