MedKoo Cat#: 524550 | Name: Carabersat

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Carabersat, also known as SB204269, is an ATP-sensitive potassium channel (K-ATP) opener potentially for the treatment of epilepsy. SB-204269 proved to be an orally-effective anticonvulsant agent. SB-204269 also selectively reduced focal electrographic seizure activity in an in vitro elevated K+ rat hippocampal slice model at concentrations (0.1-10 microM) that had no effect on normal synaptic activity and neuronal excitability.

Chemical Structure

Carabersat
Carabersat
CAS#184653-84-7

Theoretical Analysis

MedKoo Cat#: 524550

Name: Carabersat

CAS#: 184653-84-7

Chemical Formula: C20H20FNO4

Exact Mass: 357.1376

Molecular Weight: 357.38

Elemental Analysis: C, 67.22; H, 5.64; F, 5.32; N, 3.92; O, 17.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Carabersat; Sb 204269-eo; SB-204269; SB 204269; SB204269.
IUPAC/Chemical Name
N-((3R,4S)-6-acetyl-3-hydroxy-2,2-dimethylchroman-4-yl)-4-fluorobenzamide
InChi Key
RCLXAPJEFHPYEG-ZWKOTPCHSA-N
InChi Code
InChI=1S/C20H20FNO4/c1-11(23)13-6-9-16-15(10-13)17(18(24)20(2,3)26-16)22-19(25)12-4-7-14(21)8-5-12/h4-10,17-18,24H,1-3H3,(H,22,25)/t17-,18+/m0/s1
SMILES Code
C(c1ccc(cc1)F)(=O)N[C@@H]1[C@H](C(Oc2ccc(cc12)C(=O)C)(C)C)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Luszczki JJ. Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions. Pharmacol Rep. 2009 Mar-Apr;61(2):197-216. Review. PubMed PMID: 19443931. 2: Bigal ME, Krymchantowski AV, Rapoport AM. Prophylactic migraine therapy: emerging treatment options. Curr Pain Headache Rep. 2004 Jun;8(3):178-84. Review. PubMed PMID: 15115635. 3: Hovinga CA. Novel anticonvulsant medications in development. Expert Opin Investig Drugs. 2002 Oct;11(10):1387-406. Review. PubMed PMID: 12387702. 4: Bialer M, Johannessen SI, Kupferberg HJ, Levy RH, Loiseau P, Perucca E. Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI). Epilepsy Res. 2002 Sep;51(1-2):31-71. PubMed PMID: 12350382. 5: Nicolson A, Leach JP. Future prospects for the drug treatment of epilepsy. CNS Drugs. 2001;15(12):955-68. Review. PubMed PMID: 11735615. 6: Parsons AA, Bingham S, Raval P, Read S, Thompson M, Upton N. Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes. Br J Pharmacol. 2001 Apr;132(7):1549-57. PubMed PMID: 11264249; PubMed Central PMCID: PMC1572685.