Synonym
TC-H 106, TC-H106, TC-H-106, TCH-106, TCH 106, TCH106, Histone Deacetylase Inhibitor VII, Pimelic Diphenylamide 106
IUPAC/Chemical Name
N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide
InChi Key
WTKBRPXPNAKVEQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)
SMILES Code
O=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=C(C)C=C2)=O
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
339.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lee H, Kim HJ, Choi DK, Ko EN, Choi JH, Seo Y, Lee S, Kim SH, Jung S, Kim M, Kang D, Im CY, Bae GH, Jung SC, Kwon OB. Dopaminergic cell protection and alleviation of neuropsychiatric disease symptoms by VMAT2 expression through the class I HDAC inhibitor TC-H 106. Pharmacol Res Perspect. 2023 Oct;11(5):e01135. doi: 10.1002/prp2.1135. PMID: 37740715; PMCID: PMC10517640.
2: Pirmettis I, Arano Y, Tsotakos T, Okada K, Yamaguchi A, Uehara T, Morais M, Correia JD, Santos I, Martins M, Pereira S, Triantis C, Kyprianidou P, Pelecanou M, Papadopoulos M. New (99m)Tc(CO)(3) mannosylated dextran bearing S-derivatized cysteine chelator for sentinel lymph node detection. Mol Pharm. 2012 Jun 4;9(6):1681-92. doi: 10.1021/mp300015s. Epub 2012 May 10. PMID: 22519912.
3: Campos SB, Rouch LH, Seguro AC. Effects of sodium artesunate, a new antimalarial drug, on renal function. Kidney Int. 2001 Mar;59(3):1044-51. doi: 10.1046/j.1523-1755.2001.0590031044.x. PMID: 11231359.
