MedKoo Cat#: 524346 | Name: AZD-5423
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD5423 is a nonsteroidal glucocorticoid by AstraZeneca used to treat respiratory diseases and in particular chronic obstructive pulmonary disease.

Chemical Structure

AZD-5423
AZD-5423
CAS#1034148-04-3

Theoretical Analysis

MedKoo Cat#: 524346

Name: AZD-5423

CAS#: 1034148-04-3

Chemical Formula: C25H21F4N3O3

Exact Mass: 487.1519

Molecular Weight: 487.45

Elemental Analysis: C, 61.60; H, 4.34; F, 15.59; N, 8.62; O, 9.85

Price and Availability

Size Price Availability Quantity
200mg USD 1,650.00 2-3 months
500mg USD 2,950.00 2-3 months
1g USD 4,650.00 2-3 months
2g USD 7,350.00 2-3 months
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Related CAS #
No Data
Synonym
AZD-5423; AZD 5423; AZD5423
IUPAC/Chemical Name
2,2,2-Trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)-2-propanyl)acetamide
InChi Key
FCNQMDSJHADDFT-WNSKOXEYSA-N
InChi Code
InChI=1S/C25H21F4N3O3/c1-15(31-24(33)25(27,28)29)23(16-4-3-5-20(12-16)34-2)35-21-10-11-22-17(13-21)14-30-32(22)19-8-6-18(26)7-9-19/h3-15,23H,1-2H3,(H,31,33)/t15-,23-/m0/s1
SMILES Code
C[C@@H]([C@@H](c1cccc(c1)OC)Oc2ccc3c(c2)cnn3c4ccc(cc4)F)NC(=O)C(F)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 487.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Norman P. Crystalline forms of 2,2,2-trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(3-metho xyphenyl)-2-propanyl]acetamide (AZD-5423). Expert Opin Ther Pat. 2013 Sep;23(9):1239-45. doi: 10.1517/13543776.2013.820706. Epub 2013 Jul 19. PubMed PMID: 23865465.