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MedKoo Cat#: 326637 | Name: Angiotensin acetate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Angiotensin acetate, also known as (Val5)-Angiotensin II, is an angiotensin II analog that is an agonist AT1 angiotensin receptors. Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

Chemical Structure

Angiotensin acetate
Angiotensin acetate
CAS#58-49-1

Theoretical Analysis

MedKoo Cat#: 326637

Name: Angiotensin acetate

CAS#: 58-49-1

Chemical Formula: C51H73N13O14

Exact Mass: 0.0000

Molecular Weight: 1092.22

Elemental Analysis: C, 56.08; H, 6.74; N, 16.67; O, 20.51

Price and Availability

Size Price Availability Quantity
5mg USD 250.00 2 Weeks
10mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
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Synonym
Angiotensin acetate; Val5-ANG II; H-Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH; (Val5)-Angiotensin II; Human Angiotensin II Acetate Salt.
IUPAC/Chemical Name
(2S,5S,8S,11S,14S,17S)-2-((1H-imidazol-4-yl)methyl)-17-amino-1-((S)-2-(((S)-1-carboxy-2-phenylethyl)carbamoyl)pyrrolidin-1-yl)-14-(3-guanidinopropyl)-8-(4-hydroxybenzyl)-5,11-diisopropyl-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazanonadecan-19-oic acid compound with acetic acid (1:1)
InChi Key
JVCJXRGXGITABA-IAQGTVMASA-N
InChi Code
InChI=1S/C49H69N13O12.C2H4O2/c1-26(2)39(60-42(67)33(12-8-18-54-49(51)52)56-41(66)32(50)23-38(64)65)45(70)57-34(20-29-14-16-31(63)17-15-29)43(68)61-40(27(3)4)46(71)58-35(22-30-24-53-25-55-30)47(72)62-19-9-13-37(62)44(69)59-36(48(73)74)21-28-10-6-5-7-11-28;1-2(3)4/h5-7,10-11,14-17,24-27,32-37,39-40,63H,8-9,12-13,18-23,50H2,1-4H3,(H,53,55)(H,56,66)(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,64,65)(H,73,74)(H4,51,52,54);1H3,(H,3,4)/t32-,33-,34-,35-,36-,37-,39-,40-;/m0./s1
SMILES Code
CC(O)=O.O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CNC=N2)C(N3[C@@H](CCC3)C(N[C@@H](CC4=CC=CC=C4)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,092.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lin SY, Goodfriend TL. Angiotensin receptors. Am J Physiol. 1970 May;218(5):1319-28. doi: 10.1152/ajplegacy.1970.218.5.1319. PMID: 4314569. 2: Wysocki J, Wilsbacher L, Batlle D. Angiotensins and the heart: is angiotensin-(1-7) cardioprotective? Hypertension. 2015 Aug;66(2):260-2. doi: 10.1161/HYPERTENSIONAHA.115.05093. Epub 2015 Jun 15. PMID: 26077564; PMCID: PMC4624410. 3: Uijl E, Ren L, Mirabito Colafella KM, van Veghel R, Garrelds IM, Domenig O, Poglitsch M, Zlatev I, Kim JB, Huang S, Melton L, Hoorn EJ, Foster D, Danser AHJ. No evidence for brain renin-angiotensin system activation during DOCA-salt hypertension. Clin Sci (Lond). 2021 Jan 29;135(2):259-274. doi: 10.1042/CS20201239. PMID: 33404046. 4: Kawaguchi H, Kitabatake A. Renin-angiotensin system in failing heart. J Mol Cell Cardiol. 1995 Jan;27(1):201-9. doi: 10.1016/s0022-2828(08)80019-3. PMID: 7760344. 5: van Thiel BS, Góes Martini A, Te Riet L, Severs D, Uijl E, Garrelds IM, Leijten FPJ, van der Pluijm I, Essers J, Qadri F, Alenina N, Bader M, Paulis L, Rajkovicova R, Domenig O, Poglitsch M, Danser AHJ. Brain Renin-Angiotensin System: Does It Exist? Hypertension. 2017 Jun;69(6):1136-1144. doi: 10.1161/HYPERTENSIONAHA.116.08922. Epub 2017 Apr 10. PMID: 28396529. 6: de Almeida PW, Melo MB, Lima Rde F, Gavioli M, Santiago NM, Greco L, Jesus IC, Nocchi E, Parreira A, Alves MN, Mitraud L, Resende RR, Campagnole-Santos MJ, Dos Santos RA, Guatimosim S. Beneficial effects of angiotensin-(1-7) against deoxycorticosterone acetate-induced diastolic dysfunction occur independently of changes in blood pressure. Hypertension. 2015 Aug;66(2):389-95. doi: 10.1161/HYPERTENSIONAHA.114.04893. Epub 2015 Jun 15. PMID: 26077567. 7: Kamkar-Del Y, Mohebbati R, Hosseini M, Khajavirad A, Shafei MN, Rakhshandeh H. Ethyl Acetate and Aqueous Fractions of Ziziphus jujuba Prevent Acute Hypertension Induced by Angiotensin II in Rats. Cardiovasc Hematol Disord Drug Targets. 2020;20(2):108-115. doi: 10.2174/1871529X19666191119141400. PMID: 31746299. 8: Rolls BJ, Wood RJ. Role of angiotensin in thirst. Pharmacol Biochem Behav. 1977 Mar;6(3):245-50. doi: 10.1016/0091-3057(77)90020-x. PMID: 857251. 9: Ayari H. Rôles respectifs du cortisol, de l'aldostérone et de l'angiotensine II dans la physiopathologie de l'athérosclérose [Respective roles of cortisol, aldosterone and angiotensin II during pathophysiology of atherosclerosis]. Ann Biol Clin (Paris). 2013 Jul-Aug;71(4):381-8. French. doi: 10.1684/abc.2013.0868. PMID: 23906564. 10: Agarwal R, Campbell RC, Warnock DG. Oxidative stress in hypertension and chronic kidney disease: role of angiotensin II. Semin Nephrol. 2004 Mar;24(2):101-14. doi: 10.1016/j.semnephrol.2003.11.008. PMID: 15017522. 11: Nitiéma M, Soleti R, Koffi C, Belemnaba L, Mallegol P, Ouédraogo N, Kini FB, Ouédraogo S, Guissou IP, Andriantsitohaina R. Ethyl Acetate Fraction of Lannea microcarpa Engl. and K. Krause (Anacardiaceae) Trunk Barks Corrects Angiotensin II-Induced Hypertension and Endothelial Dysfunction in Mice. Oxid Med Cell Longev. 2019 Apr 28;2019:9464608. doi: 10.1155/2019/9464608. PMID: 31183001; PMCID: PMC6512010. 12: Krämer BK, Ress KM, Ulshöfer TM, Risler T. The renin-angiotensin-aldosterone system during haemodialysis with acetate or bicarbonate at different dialysate sodium concentrations. Nephrol Dial Transplant. 1987;2(6):531-6. PMID: 3126454. 13: Deliu E, Tica AA, Motoc D, Brailoiu GC, Brailoiu E. Intracellular angiotensin II activates rat myometrium. Am J Physiol Cell Physiol. 2011 Sep;301(3):C559-65. doi: 10.1152/ajpcell.00123.2011. Epub 2011 May 25. PMID: 21613610; PMCID: PMC3174567. 14: Barry EF, Abdulla MH, O'Neill J, AlMarabeh S, Beshara J, Parna-Gile E, Johns EJ. Effects of intrarenal angiotensin 1-7 infusion on renal haemodynamic and excretory function in anaesthetised two-kidney one-clip and deoxycorticosterone acetate-salt hypertensive rats. Exp Physiol. 2023 Feb;108(2):268-279. doi: 10.1113/EP090791. Epub 2022 Dec 1. PMID: 36454195. 15: Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism. Physiol Genomics. 2017 Dec 1;49(12):722-732. doi: 10.1152/physiolgenomics.00087.2017. Epub 2017 Oct 6. PMID: 28986397; PMCID: PMC5814669. 16: Hong N, Ye Z, Lin Y, Liu W, Xu N, Wang Y. Agomelatine prevents angiotensin II-induced endothelial and mononuclear cell adhesion. Aging (Albany NY). 2021 Jul 22;13(14):18515-18526. doi: 10.18632/aging.203299. Epub 2021 Jul 22. PMID: 34292876; PMCID: PMC8351686. 17: Solomon TA, Buckley JP. Inhibitory effects of central hypertensive activity of angiotensin I and II by 1-sar-8-ala-angiotensin II (saralasin acetate). J Pharm Sci. 1974 Jul;63(7):1109-13. doi: 10.1002/jps.2600630716. PMID: 4368826. 18: Uijl E, Danser AHJ. Brain angiotensin suppression in the DOCA-salt model: reversal by angiotensinogen small interfering RNA? Clin Sci (Lond). 2021 Apr 16;135(7):885-886. doi: 10.1042/CS20210199. PMID: 33835150. 19: Hales CA, Rouse ET, Kazemi H. Failure of saralasin acetate, a competitive inhibitor of angiotensin II, to diminish alveolar hypoxic vasoconstriction in the dog. Cardiovasc Res. 1977 Nov;11(6):541-6. doi: 10.1093/cvr/11.6.541. PMID: 603879. 20: De Nicola AF, Seltzer A, Tsutsumi K, Saavedra JM. Effects of deoxycorticosterone acetate (DOCA) and aldosterone on Sar1-angiotensin II binding and angiotensin-converting enzyme binding sites in brain. Cell Mol Neurobiol. 1993 Oct;13(5):529-39. doi: 10.1007/BF00711461. PMID: 8111824.