AS 35 | CAS#108427-72-1 | Antiallergy Drug

MedKoo Cat#: 524264 | Name: AS-35

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AS 35 is an antiallergic drug. AS-35 controls allergic diseases by inhibiting eosinophil activation.

Chemical Structure

AS-35

CAS#108427-72-1

Theoretical Analysis

MedKoo Cat#: 524264

Name: AS-35

CAS#: 108427-72-1

Chemical Formula: C21H20N6O4

Exact Mass: 420.1546

Molecular Weight: 420.42

Elemental Analysis: C, 59.99; H, 4.79; N, 19.99; O, 15.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AS 35; AS35; AS-35;

IUPAC/Chemical Name

4H-Pyrido(1,2-a)pyrimidin-4-one, 9-((4-acetyl-3-hydroxy-2-propylphenoxy)methyl)-3-(1H-tetrazol-5-yl)-

InChi Key

RVRGDCZGEKSIRW-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H20N6O4/c1-3-5-15-17(8-7-14(12(2)28)18(15)29)31-11-13-6-4-9-27-20(13)22-10-16(21(27)30)19-23-25-26-24-19/h4,6-10,29H,3,5,11H2,1-2H3,(H,23,24,25,26)

SMILES Code

c12ncc(c(n1cccc2COc1c(c(c(cc1)C(=O)C)O)CCC)=O)c1nnn[nH]1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 420.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kozloski GD, De Vito JM, Johnson JB, Holmes GB, Adams MA, Hunt TL. Bioequivalence of verapamil hydrochloride extended-release pellet-filled capsules when opened and sprinkled on food and when swallowed intact. Clin Pharm. 1992 Jun;11(6):539-42. PubMed PMID: 1600686. 1: Khan P, Saxena T, Adarsh KV. Tailoring between network rigidity and nanosecond transient absorption in a-Ge(x)As(35-x)Se₆₅ thin films. Opt Lett. 2015 Mar 1;40(5):768-71. doi: 10.1364/OL.40.000768. PubMed PMID: 25723428. 2: Khan P, Jain H, Adarsh KV. Role of Ge:As ratio in controlling the light-induced response of a-Ge(x)As(35-x)Se65 thin films. Sci Rep. 2014 Feb 7;4:4029. doi: 10.1038/srep04029. PubMed PMID: 24504158; PubMed Central PMCID: PMC3916963. 3: van Leeuwen R, Chakravarthy U, Vingerling JR, Brussee C, Hooghart AJ, Mulder PG, de Jong PT. Grading of age-related maculopathy for epidemiological studies: is digital imaging as good as 35-mm film? Ophthalmology. 2003 Aug;110(8):1540-4. PubMed PMID: 12917169. 4: Hamasaki Y, Zaitu M, Tsuji K, Miyazaki M, Hayasaki R, Muro E, Yamamoto S, Kobayashi I, Matsuo M, Ichimaru T, Miyazaki S. (9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido [1,2-a] pyrimidin-4-one), AS-35, inhibits leukotriene synthesis. Int J Immunopharmacol. 2000 Jul;22(7):483-90. PubMed PMID: 10785545. 5: Owens DR, Gibbins RL, Lewis PA, Wall S, Allen JC, Morton R. Screening for diabetic retinopathy by general practitioners: ophthalmoscopy or retinal photography as 35 mm colour transparencies? Diabet Med. 1998 Feb;15(2):170-5. PubMed PMID: 9507921. 6: Kawashima T, Nagaki S, Iwakaji A, Iwamoto I, Yoshida S, Tomioka H. [Inhibitory effect of AS-35. a novel antiallergic drug, on chemical mediator release from human eosinophils]. Arerugi. 1994 Dec;43(11):1326-30. Japanese. PubMed PMID: 7887808. 7: Takata H, Tamura G, Shibasaki A, Honma M, Takishima T. [Effect of AS-35 aerosol on bronchoconstriction induced by specific antigens in macacus rhesus monkeys]. Arerugi. 1993 Jul;42(7):870-7. Japanese. PubMed PMID: 7689825. 8: Watanabe-Kohno S, Yasui K, Ohkawa E, Yamamura H, Horiba M, Inoue K, Ohata K. Effect of AS-35 on agonist-induced contractions and the resting tonus of airway smooth muscles and the in vitro release of chemical mediators from passively sensitized lung fragments from humans and guinea pigs. Jpn J Pharmacol. 1992 Jun;59(2):227-33. PubMed PMID: 1279252. 9: Kasai H, Yanagihara Y. Inhibition of radiolabeled leukotriene-binding by AS-35 in guinea pig lung membrane fraction. Jpn J Pharmacol. 1992 Apr;58(4):357-64. PubMed PMID: 1405033. 10: Kasai H, Kawashima T, Omura S, Yanagihara Y. Peptide leukotriene antagonistic activity of AS-35, a new antiallergic drug. Jpn J Pharmacol. 1992 Apr;58(4):347-55. PubMed PMID: 1405032. 2: Christrup LL, Bonde J, Rasmussen SN, Rassing MR. Relative bioavailability of (+/-)-verapamil hydrochloride administered in tablets and chewing gum. Acta Pharm Nord. 1990;2(6):371-6. PubMed PMID: 2095796. 3: Marvola M, Kannikoski A, Taskinen J, Ottoila P. Assessment of bioavailability of experimental single-unit sustained release tablets of verapamil hydrochloride using the stable isotope technique. J Pharm Pharmacol. 1985 Nov;37(11):766-70. PubMed PMID: 2867156.