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MedKoo Cat#: 524256 | Name: AR-C239 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AR-C239 Dihydrochloride is a selective α2 B adrenoceptor antagonist.

Chemical Structure

AR-C239 HCl
CAS#67339-62-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 524256

Name: AR-C239 HCl

CAS#: 67339-62-2 (HCl)

Chemical Formula: C24H31Cl2N3O3

Exact Mass: 407.2209

Molecular Weight: 480.43

Elemental Analysis: C, 60.00; H, 6.50; Cl, 14.76; N, 8.75; O, 9.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
67339-62-2 (free base) 67339-62-2 (HCl).
Synonym
AR-C239 Dihydrochloride; ARC-239; ARC 239 ; ARC239; AR C-239; AR C 239 ; AR C239.
IUPAC/Chemical Name
2-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)ethyl)-4,4-dimethyl-(2H,4H)-isoquinoline-1,3-dione dihydrochloride
InChi Key
SAJKHRHHDGSJEZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H29N3O3.2ClH/c1-24(2)19-9-5-4-8-18(19)22(28)27(23(24)29)17-14-25-12-15-26(16-13-25)20-10-6-7-11-21(20)30-3;;/h4-11H,12-17H2,1-3H3;2*1H
SMILES Code
O=C1N(CCN2CCN(C3=CC=CC=C3OC)CC2)C(C(C)(C)C4=C1C=CC=C4)=O.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 480.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Huguet F. Effect of hypertension and age on alpha 1-adrenoceptors in rat brain: modulation of [3H] prazosin binding by chronic treatment with desipramine and AR-C239. Arch Int Pharmacodyn Ther. 1990 May-Jun;305:5-13. PubMed PMID: 2173510. 2: Mouillé P, Huchet AM, Chelly J, Lucet B, Doursout MF, Schmitt H. Pharmacological properties of AR-C239, 2-[2-[4(o-methoxyphenyl)-piperazine-1-Yl]-ethyl]4,4-dimethyl-1,3(2H-4H) isoquinolinedione, a new alpha-adrenoceptor blocking drug. J Cardiovasc Pharmacol. 1980;2(2):175-91. PubMed PMID: 6171685.