MedKoo Cat#: 326634 | Name: Fludalanine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fludalanine, also known as MK641, is an analogue of D-alanine that irreversibly inactivates the racemase. Fludalanine inhibits the synthetase. When combined with cycloserine, it has been found to be more active against a wide range of non-mycobacterial organisms than either fludalanine or cycloserine alone.

Chemical Structure

Fludalanine
Fludalanine
CAS#35523-45-6

Theoretical Analysis

MedKoo Cat#: 326634

Name: Fludalanine

CAS#: 35523-45-6

Chemical Formula: C3H5DFNO2

Exact Mass: 108.0445

Molecular Weight: 108.09

Elemental Analysis: C, 33.34; H, 6.53; F, 17.58; N, 12.96; O, 29.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
MK641; MK641; MK641; Fludalanine; 3-Fluoro-D-(2-2H)alanine; D-Alanine-2-d, 3-fluoro-.
IUPAC/Chemical Name
(S)-2-amino-3-fluoropropanoic-2-d acid
InChi Key
UYTSRQMXRROFPU-LIIDHCAMSA-N
InChi Code
InChI=1S/C3H6FNO2/c4-1-2(5)3(6)7/h2H,1,5H2,(H,6,7)/t2-/m1/s1/i2D
SMILES Code
N[C@@](CF)([2H])C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 108.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Musson DG, Maglietto SM, Hwang SS, Gravellese D, Bayne WF. Simultaneous quantification of cycloserine and its prodrug acetylacetonylcycloserine in plasma and urine by high-performance liquid chromatography using ultraviolet absorbance and fluorescence after post-column derivatization. J Chromatogr. 1987 Feb 20;414(1):121-9. PubMed PMID: 3571377. 2: Darland GK, Hajdu R, Kropp H, Kahan FM, Walker RW, Vandenheuvel WJ. Oxidative and defluorinative metabolism of fludalanine, 2-2H-3-fluoro-D-alanine. Drug Metab Dispos. 1986 Nov-Dec;14(6):668-73. PubMed PMID: 2877824. 3: Dickinson JM, Mitchison DA. Activity of the combination of fludalanine and cycloserine against mycobacteria in vitro. Tubercle. 1985 Jun;66(2):109-15. PubMed PMID: 4024268. 4: Musson DG, Maglietto SM, Bayne WF. Determination of the antibiotic fludalanine in plasma and urine by high-performance liquid chromatography using a packed-bed, post-column reactor with o-phthalaldehyde and 2-mercaptoethanol. J Chromatogr. 1985 Mar 22;338(2):357-67. PubMed PMID: 3998023. 5: Wise R, Andrews JM. In vitro activity of fludalanine combined with pentizidone compared with those of other agents. Antimicrob Agents Chemother. 1984 May;25(5):612-7. PubMed PMID: 6610389; PubMed Central PMCID: PMC185598. 6: Esposito AL, Pennington JE. Experimental pneumonia due to Haemophilus influenzae: observations on pathogenesis and treatment. J Infect Dis. 1984 May;149(5):728-34. PubMed PMID: 6610002.