MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 524208 | Name: AMG-0347

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMG-0347 has analgesic effects of a recently developed transient receptor potential vanilloid 1 (TRPV1) antagonist. The effect of either AMG0347 or morphine was tested for its effects on guarding pain score, heat withdrawal latency, and mechanical withdrawal threshold.

Chemical Structure

AMG-0347
AMG-0347
CAS#946615-43-6

Theoretical Analysis

MedKoo Cat#: 524208

Name: AMG-0347

CAS#: 946615-43-6

Chemical Formula: C24H26F3N3O2

Exact Mass: 445.1977

Molecular Weight: 445.48

Elemental Analysis: C, 64.71; H, 5.88; F, 12.79; N, 9.43; O, 7.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
AMG-0347; AMG 0347; AMG0347; UNII-CD7L9290QR;
IUPAC/Chemical Name
2-Propenamide, 3-(2-(1-piperidinyl)-6-(trifluoromethyl)-3-pyridinyl)-N-(5,6,7,8-tetrahydro-7-hydroxy-1-naphthalenyl)-, (2E)-
InChi Key
YCDWBIUKUBHSKQ-FMIVXFBMSA-N
InChi Code
InChI=1S/C24H26F3N3O2/c25-24(26,27)21-11-8-17(23(29-21)30-13-2-1-3-14-30)9-12-22(32)28-20-6-4-5-16-7-10-18(31)15-19(16)20/h4-6,8-9,11-12,18,31H,1-3,7,10,13-15H2,(H,28,32)/b12-9+
SMILES Code
c1cc2c(c(c1)NC(=O)/C=C/c3ccc(nc3N4CCCCC4)C(F)(F)F)CC(CC2)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 445.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Garami A, Pakai E, Oliveira DL, Steiner AA, Wanner SP, Almeida MC, Lesnikov VA, Gavva NR, Romanovsky AA. Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci. 2011 Feb 2;31(5):1721-33. doi: 10.1523/JNEUROSCI.4671-10.2011. PubMed PMID: 21289181; PubMed Central PMCID: PMC3430466. 2: Wu C, Gavva NR, Brennan TJ. Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision. Anesthesiology. 2008 Jun;108(6):1100-8. doi: 10.1097/ALN.0b013e31817302b3. PubMed PMID: 18497612. 3: Montell C, Caterina MJ. Thermoregulation: channels that are cool to the core. Curr Biol. 2007 Oct 23;17(20):R885-7. Review. PubMed PMID: 17956748. 4: Steiner AA, Turek VF, Almeida MC, Burmeister JJ, Oliveira DL, Roberts JL, Bannon AW, Norman MH, Louis JC, Treanor JJ, Gavva NR, Romanovsky AA. Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci. 2007 Jul 11;27(28):7459-68. PubMed PMID: 17626206.