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MedKoo Cat#: 524205 | Name: Ametantrone Acetate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ametantrone Acetate is a topoisomerase II inhibitor of the anthrapyrazole family that causes covalent cross-links in DNA.

Chemical Structure

Ametantrone Acetate
Ametantrone Acetate
CAS#70711-40-9

Theoretical Analysis

MedKoo Cat#: 524205

Name: Ametantrone Acetate

CAS#: 70711-40-9

Chemical Formula: C26H36N4O8

Exact Mass:

Molecular Weight: 532.59

Elemental Analysis: C, 58.63; H, 6.81; N, 10.52; O, 24.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ametantrone Acetate; CI-881.
IUPAC/Chemical Name
1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione diacetate
InChi Key
IGCAUIJHGNYDKE-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H28N4O4.2C2H4O2/c27-13-11-23-7-9-25-17-5-6-18(26-10-8-24-12-14-28)20-19(17)21(29)15-3-1-2-4-16(15)22(20)30;2*1-2(3)4/h1-6,23-28H,7-14H2;2*1H3,(H,3,4)
SMILES Code
O=C1C2=C(C=CC=C2)C(C3=C(NCCNCCO)C=CC(NCCNCCO)=C13)=O.CC(O)=O.CC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 532.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kuhn JG, Balmer CE, Ludden TM, Loesch DM, Von Hoff DD, Bender JF, Grillo-Lopez AJ. Pharmacokinetics of ametantrone acetate (NSC-287513). Cancer Chemother Pharmacol. 1987;19(2):133-7. PubMed PMID: 3568271. 2: Petrere JA, Kim SN, Anderson JA, Fitzgerald JE, de la Iglesia FA, Schardein JL. Teratology studies of ametantrone acetate in rats and rabbits. Teratology. 1986 Dec;34(3):271-8. PubMed PMID: 3798363. 3: Watkins JR, Kim SN, Jayasekara U, Anderson JA, Fitzgerald JE, de la Iglesia FA. Preclinical toxicity of the new antineoplastic agent, ametantrone acetate, in mice and dogs. J Appl Toxicol. 1986 Feb;6(1):31-6. PubMed PMID: 3958426. 4: Gams RA, Ostroy F, Bender JF, Grillo-López AJ. A phase I trial of ametantrone acetate (NSC-287513). Invest New Drugs. 1985;3(4):383-8. PubMed PMID: 4086246.