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MedKoo Cat#: 524169 | Name: AM-114
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AM 114 is a proteasome inhibitor. It is an inhibitor of chymotrypsin-like activity of the 20S proteasome. Also, AM-114 displays anticancer activity, inhibits cell growth in human colon cancer HCT116 p53+/+ cells.

Chemical Structure

AM-114
AM-114
CAS#856849-35-9

Theoretical Analysis

MedKoo Cat#: 524169

Name: AM-114

CAS#: 856849-35-9

Chemical Formula: C20H21B2NO5

Exact Mass: 377.1606

Molecular Weight: 377.01

Elemental Analysis: C, 63.72; H, 5.61; B, 5.74; N, 3.72; O, 21.22

Price and Availability

Size Price Availability Quantity
10mg USD 330.00 2 Weeks
25mg USD 550.00 2 Weeks
50mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
AM-114; AM 114; AM114; Proteasome Inhibitor IX;
IUPAC/Chemical Name
(((1-Methyl-4-oxopiperidine-3,5-diylidene)bis(methaneylylidene))bis(4,1-phenylene))diboronic acid
InChi Key
SRPIKXGUPAKTIZ-OTYYAQKOSA-N
InChi Code
InChI=1S/C20H21B2NO5/c1-23-12-16(10-14-2-6-18(7-3-14)21(25)26)20(24)17(13-23)11-15-4-8-19(9-5-15)22(27)28/h2-11,25-28H,12-13H2,1H3/b16-10+,17-11+
SMILES Code
O=C(/C(CN(C)C3)=C/C2=CC=C(B(O)O)C=C2)/C3=C/C1=CC=C(B(O)O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 377.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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