Synonym
AL-3152; AL 3152; AL3152;
IUPAC/Chemical Name
Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione, 2,7-difluoro-4-methoxy-
InChi Key
FYDPXVSFSSBHGW-MRXNPFEDSA-N
InChi Code
InChI=1S/C16H10F2N2O3/c1-23-12-6-8(18)5-11-13(12)9-3-2-7(17)4-10(9)16(11)14(21)19-15(22)20-16/h2-6H,1H3,(H2,19,20,21,22)/t16-/m1/s1
SMILES Code
N1[C@@]2(c3cc(ccc3c3c(cc(cc23)F)OC)F)C(=O)NC1=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
316.26
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Robison WG Jr, Laver NM, Jacot JL, Chandler ML, York BM, Glover JP. Efficacy of treatment after measurable diabeticlike retinopathy in galactose-fed rats. Invest Ophthalmol Vis Sci. 1997 May;38(6):1066-73. PubMed PMID: 9152226.
2: Park YH, Mayer PR, Barker R, DuPriest M, Griffin BW, Williams GW, York BM, Slattery JT. Comparison of the pharmacokinetics and pharmacodynamics of the aldose reductase inhibitors, AL03152 (RS), AL03802 (R), and AL03803 (S). Pharm Res. 1993 Apr;10(4):593-7. PubMed PMID: 8483844.
3: Kiss AD, Haggard K, Veltman JC, Ziegler DM. Oxidation of aldose reductase inhibitors ALO-4114 and ALO-3152 catalyzed by liver microsomes. Drug Metab Dispos. 1992 Nov-Dec;20(6):948-53. PubMed PMID: 1362951.
4: Chien JY, Banfield CR, Brazzell RK, Mayer PR, Slattery JT. Saturable tissue binding and imirestat pharmacokinetics in rats. Pharm Res. 1992 Apr;9(4):469-73. PubMed PMID: 1495891.
5: Reddy VN, Lin LR, Giblin FJ, Lou M, Kador PF, Kinoshita JH. The efficacy of aldose reductase inhibitors on polyol accumulation in human lens and retinal pigment epithelium in tissue culture. J Ocul Pharmacol. 1992 Spring;8(1):43-52. PubMed PMID: 1402294.
