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MedKoo Cat#: 524139 | Name: AG-205
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AG-205 is a progesterone receptor membrane component 1 inhibitor. AG-205 alters the spectroscopic properties of the Pgrmc1-heme complex. AG-205 inhibits cancer cell viability and cancer cell progression.

Chemical Structure

AG-205
CAS#442656-02-2

Theoretical Analysis

MedKoo Cat#: 524139

Name: AG-205

CAS#: 442656-02-2

Chemical Formula: C22H23ClN6OS

Exact Mass: 454.1343

Molecular Weight: 454.98

Elemental Analysis: C, 58.08; H, 5.10; Cl, 7.79; N, 18.47; O, 3.52; S, 7.05

Price and Availability

Size Price Availability Quantity
5mg USD 400.00 2 Weeks
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Related CAS #
No Data
Synonym
AG 205; AG-205; AG205;
IUPAC/Chemical Name
Ethanone, 2-((1-(4-chlorophenyl)-1H-tetrazol-5-yl)thio)-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido(4,3-b)indol-5-yl)-
InChi Key
GJNBAISSZRNGTM-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H23ClN6OS/c1-14-3-8-19-17(11-14)18-12-27(2)10-9-20(18)28(19)21(30)13-31-22-24-25-26-29(22)16-6-4-15(23)5-7-16/h3-8,11,18,20H,9-10,12-13H2,1-2H3
SMILES Code
CC1=CC2=C(N(C(CSC3=NN=NN3C4=CC=C(Cl)C=C4)=O)C5C2CN(C)CC5)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 454.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yeh DW, Chen YS, Lai CY, Liu YL, Lu CH, Lo JF, Chen L, Hsu LC, Luo Y, Xiang R, Chuang TH. Downregulation of COMMD1 by miR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cells. Cell Death Differ. 2016 May;23(5):841-52. doi: 10.1038/cdd.2015.147. Epub 2015 Nov 20. PubMed PMID: 26586569; PubMed Central PMCID: PMC4832103. 2: Cruz LJ, Rosalia RA, Kleinovink JW, Rueda F, Löwik CW, Ossendorp F. Targeting nanoparticles to CD40, DEC-205 or CD11c molecules on dendritic cells for efficient CD8(+) T cell response: a comparative study. J Control Release. 2014 Oct 28;192:209-18. doi: 10.1016/j.jconrel.2014.07.040. Epub 2014 Jul 25. PubMed PMID: 25068703. 3: Dhodapkar MV, Sznol M, Zhao B, Wang D, Carvajal RD, Keohan ML, Chuang E, Sanborn RE, Lutzky J, Powderly J, Kluger H, Tejwani S, Green J, Ramakrishna V, Crocker A, Vitale L, Yellin M, Davis T, Keler T. Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205. Sci Transl Med. 2014 Apr 16;6(232):232ra51. doi: 10.1126/scitranslmed.3008068. PubMed PMID: 24739759. 4: Swetz KM, Matlock DD, Ferris H, Hunt S. Mechanical circulatory support in advanced heart failure #205, 2nd ed. J Palliat Med. 2013 Aug;16(8):979-80. doi: 10.1089/jpm.2013.9489. Epub 2013 Jun 14. PubMed PMID: 23767951; PubMed Central PMCID: PMC3727522. 5: Meixlsperger S, Leung CS, Rämer PC, Pack M, Vanoaica LD, Breton G, Pascolo S, Salazar AM, Dzionek A, Schmitz J, Steinman RM, Münz C. CD141+ dendritic cells produce prominent amounts of IFN-α after dsRNA recognition and can be targeted via DEC-205 in humanized mice. Blood. 2013 Jun 20;121(25):5034-44. doi: 10.1182/blood-2012-12-473413. Epub 2013 Mar 12. PubMed PMID: 23482932; PubMed Central PMCID: PMC3689250. 6: Cho HJ, Liu G, Jin SM, Parisiadou L, Xie C, Yu J, Sun L, Ma B, Ding J, Vancraenenbroeck R, Lobbestael E, Baekelandt V, Taymans JM, He P, Troncoso JC, Shen Y, Cai H. MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein. Hum Mol Genet. 2013 Feb 1;22(3):608-20. doi: 10.1093/hmg/dds470. Epub 2012 Nov 2. PubMed PMID: 23125283; PubMed Central PMCID: PMC3542867. 7: Flacher V, Tripp CH, Haid B, Kissenpfennig A, Malissen B, Stoitzner P, Idoyaga J, Romani N. Skin langerin+ dendritic cells transport intradermally injected anti-DEC-205 antibodies but are not essential for subsequent cytotoxic CD8+ T cell responses. J Immunol. 2012 Mar 1;188(5):2146-55. doi: 10.4049/jimmunol.1004120. Epub 2012 Jan 30. PubMed PMID: 22291181; PubMed Central PMCID: PMC3288813. 8: Tsuji T, Matsuzaki J, Kelly MP, Ramakrishna V, Vitale L, He LZ, Keler T, Odunsi K, Old LJ, Ritter G, Gnjatic S. Antibody-targeted NY-ESO-1 to mannose receptor or DEC-205 in vitro elicits dual human CD8+ and CD4+ T cell responses with broad antigen specificity. J Immunol. 2011 Jan 15;186(2):1218-27. doi: 10.4049/jimmunol.1000808. Epub 2010 Dec 13. PubMed PMID: 21149605. 9: Song H, Bu G. MicroRNA-205 inhibits tumor cell migration through down-regulating the expression of the LDL receptor-related protein 1. Biochem Biophys Res Commun. 2009 Oct 16;388(2):400-5. doi: 10.1016/j.bbrc.2009.08.020. Epub 2009 Aug 8. PubMed PMID: 19665999; PubMed Central PMCID: PMC2741500. 10: López de Maturana R, Treece-Birch J, Abidi F, Findlay JB, Donnelly D. Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues. Protein Pept Lett. 2004 Feb;11(1):15-22. PubMed PMID: 14965274. 11: Macor JE, Gurley D, Lanthorn T, Loch J, Mack RA, Mullen G, Tran O, Wright N, Gordon JC. The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist. Bioorg Med Chem Lett. 2001 Feb 12;11(3):319-21. PubMed PMID: 11212100. 12: Colao A, De Rosa M, Sarnacchiaro F, Di Sarno A, Landi ML, Iervolino E, Zarrilli S, Merola B, Lombardi G. Chronic treatment with CV 205-502 restores the gonadal function in hyperprolactinemic males. Eur J Endocrinol. 1996 Nov;135(5):548-52. PubMed PMID: 8980156. 13: Bodmer CW, Atkin SL, Savage MW, Masson EA, White MC. Effects of quinagolide (CV 205-502), a selective D2-agonist, on vascular reactivity in patients with a prolactin-secreting adenoma. Clin Endocrinol (Oxf). 1995 Jul;43(1):49-53. PubMed PMID: 7641411. 14: Lombardi G, Colao A, Ferone D, Sarnacchiaro F, Marzullo P, Di Sarno A, Rossi E, Merola B. CV 205-502 treatment in therapy-resistant acromegalic patients. Eur J Endocrinol. 1995 May;132(5):559-64. PubMed PMID: 7749496. 15: Jaquet P. CV 205-502: a more effective dopamine agonist in the treatment of acromegaly? Eur J Endocrinol. 1995 May;132(5):557-8. PubMed PMID: 7749495. 16: Merola B, Sarnacchiaro F, Colao A, Di Somma C, Di Sarno A, Ferone D, Selleri A, Landi ML, Schettini G, Nappi C, et al. Positive response to compound CV 205-502 in hyperprolactinemic patients resistant to or intolerant of bromocriptine. Gynecol Endocrinol. 1994 Sep;8(3):175-81. PubMed PMID: 7847102. 17: Jankowska E, Bidzinski A, Kostowski W. Alcohol drinking in rats treated with 5,7-dihydroxytryptamine: effect of 8-OH-DPAT and tropisetron (ICS 205-930). Alcohol. 1994 Jul-Aug;11(4):283-8. PubMed PMID: 7945981. 18: Glaser B, Nesher Y, Barziliai S. Long-term treatment of bromocriptine-intolerant prolactinoma patients with CV 205-502. J Reprod Med. 1994 Jun;39(6):449-54. PubMed PMID: 7932398. 19: Tauveron I, Gesta JM, Jalenques I, Thieblot P. Acute overdose of a new dopamine agonist, CV 205-502. Clin Endocrinol (Oxf). 1994 Apr;40(4):551-3. PubMed PMID: 7910531. 20: Merola B, Sarnacchiaro F, Colao A, Di Somma C, Di Sarno A, Landi ML, Marzullo P, Panza N, Battista C, Lombardi G. CV 205-502 in the treatment of tumoral and non-tumoral hyperprolactinemic states. Biomed Pharmacother. 1994;48(3-4):167-74. PubMed PMID: 7993981.