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MedKoo Cat#: 318897 | Name: Travoprost
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a synthetic prostaglandin analog (or more specifically, an analog of prostaglandin F2α) that works by increasing the outflow of aqueous fluid from the eyes.

Chemical Structure

Travoprost
Travoprost
CAS#157283-68-6

Theoretical Analysis

MedKoo Cat#: 318897

Name: Travoprost

CAS#: 157283-68-6

Chemical Formula: C26H35F3O6

Exact Mass: 500.2386

Molecular Weight: 500.55

Elemental Analysis: C, 62.39; H, 7.05; F, 11.39; O, 19.18

Price and Availability

Size Price Availability Quantity
5mg USD 550.00
10mg USD 900.00
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Related CAS #
No Data
Synonym
Travoprost, AL-6221, Travatan, Travoprostin
IUPAC/Chemical Name
propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate
InChi Key
MKPLKVHSHYCHOC-AHTXBMBWSA-N
InChi Code
InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1
SMILES Code
O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)COC2=CC=CC(C(F)(F)F)=C2)[C@H](O)C[C@@H]1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 500.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sridharan K. Systemic adverse drug events to topical prostaglandin analogs for treating glaucoma: a retrospective focused pharmacovigilance study. BMC Ophthalmol. 2024 Dec 31;24(1):554. doi: 10.1186/s12886-024-03823-w. PMID: 39741235; PMCID: PMC11686995. 2: Huston J, Paauw M, Orey D, Centner A, Hasan A, Shetty R, Freidl K, Goldfaden R. Travoprost Intracameral Implant: A Review on the Novel Treatment Modality for Open-Angle Glaucoma and Ocular Hypertension. Ann Pharmacother. 2024 Dec 10:10600280241291911. doi: 10.1177/10600280241291911. Epub ahead of print. PMID: 39658880. 3: Li W, Chen X, Chen S, Lv Z, Tang J, Li N. Changes in prostaglandin-associated periorbital syndrome: a self-controlled and prospective study. Cutan Ocul Toxicol. 2024 Dec 2:1-8. doi: 10.1080/15569527.2024.2431570. Epub ahead of print. PMID: 39620977. 4: Kim YK, Woo IS, Park CG, Kim A, Choi JD, Son KH, Han KM. Green extraction of prostaglandin analogs in cosmetics using deep eutectic solvents and detection via LC-MS/MS. J Chromatogr A. 2025 Jan 4;1739:465516. doi: 10.1016/j.chroma.2024.465516. Epub 2024 Nov 13. PMID: 39579545. 5: Zheng X, Wang C, Fan Y, Hong Y, Bao H, Zhang E, Jin Y, Yang P, Li L, Wang J, Chen S, Elsheikh A, Bao F. Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost. Invest Ophthalmol Vis Sci. 2024 Nov 4;65(13):35. doi: 10.1167/iovs.65.13.35. PMID: 39546291; PMCID: PMC11580291. 6: Wu SN, Huang C, Wang YQ, Li X, Zhang SQ, Chen XD, Qin DY, Zhu L, Wen JY, Luo NC, Hu J, Liu Z. Adverse events of topical ocular prostaglandin medications for glaucoma treatment: a pharmacovigilance study based on the FAERS database. Ther Adv Drug Saf. 2024 Oct 16;15:20420986241285929. doi: 10.1177/20420986241285929. PMID: 39429679; PMCID: PMC11487502. 7: Durmuş Ece BŞ, Yozgat Z, Bayramlı H, Ece B, Aydin S. Evaluation of the Effect of Topical Prostaglandin Analog Treatment on Orbital Structures in Open-Angle Glaucoma with Computed Tomography. J Clin Med. 2024 Sep 28;13(19):5808. doi: 10.3390/jcm13195808. PMID: 39407871; PMCID: PMC11478186. 8: Yang TK, Kuo HT, Ju YJ, Chen CY, Chen WH, Wu AY, Lin CJ, Lee CC, Ho JH. Comparative analysis of medical treatments for long-term control of normal tension glaucoma: A systematic review and model-based network meta-analysis. Clin Exp Ophthalmol. 2024 Oct 9. doi: 10.1111/ceo.14447. Epub ahead of print. PMID: 39385332. 9: Chen YQ, Yao YH, Ye Q, Wang XH, Lin Y, Zhu YH. [Three-year results of XEN gel stent implantation in the treatment of glaucoma]. Zhonghua Yan Ke Za Zhi. 2024 Oct 11;60(10):845-851. Chinese. doi: 10.3760/cma.j.cn112142-20240513-00225. PMID: 39375143. 10: Wu SN, Chen XD, Zhang QH, Wang YQ, Yan D, Xu CS, Wang SP, Zhu L, Qin DY, Guo SJ, Chen L, Liu YW, Huang C, Hu J, Liu Z. Drug-Related Keratitis: A Real-World FDA Adverse Event Reporting System Database Study. Transl Vis Sci Technol. 2024 Sep 3;13(9):17. doi: 10.1167/tvst.13.9.17. PMID: 39287587; PMCID: PMC11421680. 11: Singh IP, Berdahl JP, Sarkisian SR Jr, Voskanyan LA, Ang RE, Doan LV, Applegate D, Shen Y, Katz LJ, Kothe AC, Navratil T. Long-Term Safety and Efficacy Evaluation of Travoprost Intracameral Implant Based on Pooled Analyses from Two Phase III Trials. Drugs. 2024 Oct;84(10):1299-1311. doi: 10.1007/s40265-024-02074-9. Epub 2024 Sep 6. PMID: 39240530; PMCID: PMC11512891. 12: Contreras-Salinas H, Romero-López MS, Olvera-Montaño O, Rodríguez-Herrera LY. Prostaglandin analogues signal detection by data mining in the FDA Adverse Event Reporting System database. BMJ Open Ophthalmol. 2024 Aug 29;9(1):e001764. doi: 10.1136/bmjophth-2024-001764. PMID: 39209740; PMCID: PMC11367404. 13: Hsueh CM, Tsai CH, Huang JC, Lee SH, Wang TJ, Guo SP. One-year experience with latanoprostene bunod ophthalmic solution 0.024% in clinical practice: A retrospective observational study. PLoS One. 2024 Aug 22;19(8):e0307132. doi: 10.1371/journal.pone.0307132. PMID: 39173013; PMCID: PMC11341023. 14: Pourriyahi H, Hosseini NS, Nooshabadi MP, Pourriahi H, Baradaran HR, Abtahi- Naeini B, Goodarzi A. Utility of prostaglandin analogues and phosphodiesterase inhibitors as promising last resorts for the treatment of vitiligo: A systematic review, from mechanisms of action to mono-, combination and comparative therapies. J Cosmet Dermatol. 2024 Nov;23(11):3466-3487. doi: 10.1111/jocd.16468. Epub 2024 Aug 19. PMID: 39158214. 15: Bacharach J, McLaurin EB, Silverstein S, Amrane M, Garrigue JS, Ismail D, Flynn WJ; Catiolanze Phase 2 study group. Efficacy and Safety of a Preservative- Free Latanoprost Cationic Emulsion in Patients with Open-Angle Glaucoma and Concurrent Ocular Surface Disease: A Randomized Phase 2 Study. J Ocul Pharmacol Ther. 2024 Nov;40(9):553-561. doi: 10.1089/jop.2024.0029. Epub 2024 Aug 16. PMID: 39150378. 16: Takada Y, Yasuda S, Sumioka T, Okada Y, Tamura T, Yamanaka O, Saika S. Effects of Ripasudil Hydrochloride on Epithelial Repair in a Mouse Cornea. Curr Eye Res. 2024 Dec;49(12):1215-1222. doi: 10.1080/02713683.2024.2378018. Epub 2024 Jul 21. PMID: 39034645. 17: Bacharach J, Doan LV, Stephens KG, Usner DW, Kothe AC, Katz LJ, Navratil T. Travoprost Intracameral Implant Demonstrates Superior IOP Lowering Versus Topical Prostaglandin Analog Monotherapy in Patients with Open-Angle Glaucoma or Ocular Hypertension. Ophthalmol Ther. 2024 Sep;13(9):2357-2367. doi: 10.1007/s40123-024-00992-1. Epub 2024 Jul 10. PMID: 38985408; PMCID: PMC11341799. 18: Elhusseiny AM, Aref AA. Sustained Release Therapies with the Prostaglandin Analogues Intracameral Implants. Ophthalmol Ther. 2024 Jul;13(7):1833-1839. doi: 10.1007/s40123-024-00965-4. Epub 2024 May 18. PMID: 38761359; PMCID: PMC11178720. 19: iDose TR - a travoprost implant for glaucoma. Med Lett Drugs Ther. 2024 Apr 29;66(1701):70-71. doi: 10.58347/tml.2024.1701d. PMID: 38691647. 20: Bhartiya S, Ichhpujani P, Parmar UPS, Kapoor S, Kaundal S, Kumar S. Glaucoma Drug Prescription Pattern in North India: Public vs Private Sector Hospitals. J Curr Glaucoma Pract. 2024 Jan-Mar;18(1):16-22. doi: 10.5005/jp- journals-10078-1438. PMID: 38585162; PMCID: PMC10997958.