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MedKoo Cat#: 524111 | Name: ABT-116

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ABT-116 is an antagonist of transient receptor potential vanilloid type 1.

Chemical Structure

ABT-116
ABT-116
CAS#1008529-42-7

Theoretical Analysis

MedKoo Cat#: 524111

Name: ABT-116

CAS#: 1008529-42-7

Chemical Formula: C23H27F3N4O

Exact Mass: 432.2137

Molecular Weight: 432.48

Elemental Analysis: C, 63.87; H, 6.29; F, 13.18; N, 12.95; O, 3.70

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
ABT-116; ABT 116; ABT116;
IUPAC/Chemical Name
1-(2-(3,3-dimethylbutyl)-4-(trifluoromethyl)benzyl)-3-(1-methyl-1H-indazol-4-yl)urea
InChi Key
SMJCAASNPAKOIB-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H27F3N4O/c1-22(2,3)11-10-15-12-17(23(24,25)26)9-8-16(15)13-27-21(31)29-19-6-5-7-20-18(19)14-28-30(20)4/h5-9,12,14H,10-11,13H2,1-4H3,(H2,27,29,31)
SMILES Code
CC(C)(CCc1c(CNC(Nc2c3cnn(C)c3ccc2)=O)ccc(C(F)(F)F)c1)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 432.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Niyom S, Mama KR, Gustafson DL, Rezende ML. Single- and multiple dose pharmacokinetics and multiple dose pharmacodynamics of oral ABT-116 (a TRPV1 antagonist) in dogs. J Vet Pharmacol Ther. 2015 Aug;38(4):336-43. doi: 10.1111/jvp.12180. Epub 2014 Nov 5. PubMed PMID: 25376244. 2: Malek S, Sample SJ, Schwartz Z, Nemke B, Jacobson PB, Cozzi EM, Schaefer SL, Bleedorn JA, Holzman G, Muir P. Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis. BMC Vet Res. 2012 Oct 4;8:185. doi: 10.1186/1746-6148-8-185. PubMed PMID: 23035739; PubMed Central PMCID: PMC3527270. 3: Niyom S, Mama KR, De Rezende ML. Comparison of the analgesic efficacy of oral ABT-116 administration with that of transmucosal buprenorphine administration in dogs. Am J Vet Res. 2012 Apr;73(4):476-81. doi: 10.2460/ajvr.73.4.476. PubMed PMID: 22452493. 4: Cathcart CJ, Johnston SA, Reynolds LR, Al-Nadaf S, Budsberg SC. Efficacy of ABT-116, an antagonist of transient receptor potential vanilloid type 1, in providing analgesia for dogs with chemically induced synovitis. Am J Vet Res. 2012 Jan;73(1):19-26. doi: 10.2460/ajvr.73.1.19. PubMed PMID: 22204284. 5: Brown BS, Keddy R, Perner RJ, DiDomenico S, Koenig JR, Jinkerson TK, Hannick SM, McDonald HA, Bianchi BR, Honore P, Puttfarcken PS, Moreland RB, Marsh KC, Faltynek CR, Lee CH. Discovery of TRPV1 antagonist ABT-116. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3291-4. doi: 10.1016/j.bmcl.2010.04.047. Epub 2010 Apr 14. PubMed PMID: 20457518.