Synonym
D-64131; D 64131; D64131.
IUPAC/Chemical Name
(5-Methoxy-1H-indol-2-yl)phenylmethanone
InChi Key
ICMIJSRDISNKOC-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H13NO2/c1-19-13-7-8-14-12(9-13)10-15(17-14)16(18)11-5-3-2-4-6-11/h2-10,17H,1H3
SMILES Code
O=C(C(N1)=CC2=C1C=CC(OC)=C2)C3=CC=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
251.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Putey A, Popowycz F, Do QT, Bernard P, Talapatra SK, Kozielski F, Galmarini
CM, Joseph B. Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives
as tubulin polymerization inhibitors: synthesis and structure--activity
relationship studies. J Med Chem. 2009 Oct 8;52(19):5916-25. doi:
10.1021/jm900476c. PubMed PMID: 19743863.
2: Beckers T, Reissmann T, Schmidt M, Burger AM, Fiebig HH, Vanhoefer U, Pongratz
H, Hufsky H, Hockemeyer J, Frieser M, Mahboobi S. 2-aroylindoles, a novel class
of potent, orally active small molecule tubulin inhibitors. Cancer Res. 2002 Jun
1;62(11):3113-9. PubMed PMID: 12036922.
