Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic drug originally sold under the brand name Orinase. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin by the pancreas. Since the pancreas must synthesize insulin for this drug to work, it is not effective in the management of type 1 diabetes. It is not routinely used due to a higher incidence of adverse effects compared to newer, second-generation sulfonylureas, such as glyburide. It generally has a short duration of action due to its rapid metabolism, so is safe for use in elderly diabetic patients.
MedKoo Cat#: 318885
Name: Tolbutamide
CAS#: 64-77-7
Chemical Formula: C12H18N2O3S
Exact Mass: 270.1038
Molecular Weight: 270.35
Elemental Analysis: C, 53.31; H, 6.71; N, 10.36; O, 17.75; S, 11.86
The following data is based on the product molecular weight 270.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
