NSC59984 is a p53 pathway activator. NSC59984 restores wild-type p53 signaling via p73 activation, specifically in mutant p53-expressing colorectal cancer cells. NSC59984 synergizes with CPT11 to induce cell death in mutant p53-expressing colorectal cancer cells and inhibits mutant p53-associated colon tumor xenograft growth in a p73-dependent manner in vivo. NSC59984 as a promising lead compound for anticancer therapy that acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling.
MedKoo Cat#: 407327
Name: NSC59984
CAS#: 803647-40-7
Chemical Formula: C12H15N3O4
Exact Mass: 265.1063
Molecular Weight: 265.27
Elemental Analysis: C, 54.33; H, 5.70; N, 15.84; O, 24.12
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 25.0 | 94.24 | |
| DMSO | 32.1 | 121.05 | |
| Ethanol | 29.0 | 109.32 |
The following data is based on the product molecular weight 265.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
