MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 318674 | Name: Rocuronium Bromide
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate endotracheal intubation by providing skeletal muscle relaxation. It is used for both standard and rapid sequence induction (RSI).

Chemical Structure

Rocuronium Bromide
Rocuronium Bromide
CAS#119302-91-9 (bromide)

Theoretical Analysis

MedKoo Cat#: 318674

Name: Rocuronium Bromide

CAS#: 119302-91-9 (bromide)

Chemical Formula: C32H53BrN2O4

Exact Mass: 0.0000

Molecular Weight: 609.68

Elemental Analysis: C, 63.04; H, 8.76; Br, 13.11; N, 4.59; O, 10.50

Price and Availability

Size Price Availability Quantity
100mg USD 150.00 2 Weeks
200mg USD 250.00 2 Weeks
500mg USD 550.00 2 Weeks
1g USD 950.00 2 Weeks
2g USD 1,650.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
143558-00-3 (free base); 119302-91-9 (bromide)
Synonym
Rocuronium Bromide; Rocuronium Br; Zemuron; Rocuronium (Bromide); Esmeron; Esmeron; Esmerone; ORG 9426; ORG9426; ORG-9426;
IUPAC/Chemical Name
[(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enylpyrrolidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate;bromide
InChi Key
OYTJKRAYGYRUJK-FMCCZJBLSA-M
InChi Code
InChI=1S/C32H53N2O4.BrH/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35;/h5,23-30,36H,1,6-21H2,2-4H3;1H/q+1;/p-1/t23-,24+,25-,26-,27-,28-,29-,30-,31-,32-;/m0./s1
SMILES Code
C[C@@]12[C@](C[C@H]([N+]3(CC=C)CCCC3)[C@@H]2OC(C)=O)([H])[C@]([C@]4([H])CC1)([H])CC[C@@]([C@]4(C)C5)([H])C[C@H](O)[C@H]5N6CCOCC6.[Br-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 119302-91-9 ( Rocuroniumbromide); 143558-00-3 ( Rocuronium cation).
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Rocuronium bromide has antagonistic properties that target the neuromuscular nicotinic acetylcholine receptor. Rocuronium bromide competitively binds to the nicotinic receptor at the motor end plate, and antagonizes acetylcholine binding.
In vitro activity:
The data from this study suggest that rocuronium bromide could repress the PI3K/AKT/mTOR signaling pathway and autophagy to block the CXCL12 expression in CAFs, thereby weakening the CXCL12-mediated EC tumor progression. This study provides evidence that rocuronium bromide inhibits esophageal cancer. Reference: J Transl Med. 2023 Apr 8;21(1):248. https://pubmed.ncbi.nlm.nih.gov/37029408/
In vivo activity:
This study evaluated the potency and time course of rocuronium-induced neuromuscular block after prolonged pretreatment with clonidine in rabbits. The effects of rocuronium with pretreatment of clonidine may have been increased, but no difference in the duration of action in comparison with the control group. Reference: Korean J Anesthesiol. 2010 Sep;59(3):190-5. https://pubmed.ncbi.nlm.nih.gov/20877704/
Solvent mg/mL mM
Solubility
DMSO 122.0 200.10
Ethanol 122.0 200.10
Water 122.0 200.10
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 609.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Li J, Gu X, Wan G, Wang Y, Chen K, Chen Q, Lu C. Rocuronium bromide suppresses esophageal cancer via blocking the secretion of C-X-C motif chemokine ligand 12 from cancer associated fibroblasts. J Transl Med. 2023 Apr 8;21(1):248. doi: 10.1186/s12967-023-04081-y. PMID: 37029408; PMCID: PMC10082495. 2. Chompunud Na Ayudhya C, Amponnawarat A, Roy S, Oskeritzian CA, Ali H. MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants. Cells. 2021 Jan 15;10(1):156. doi: 10.3390/cells10010156. PMID: 33467419; PMCID: PMC7830812. 3. Suzuki K, Sunaga H, Yamakawa K, Suga Y, Kondo I, Tsubokawa T, Uezono S. Intravenous infusion of rocuronium bromide prolongs emergence from propofol anesthesia in rats. PLoS One. 2021 Feb 11;16(2):e0246858. doi: 10.1371/journal.pone.0246858. PMID: 33571289; PMCID: PMC7877640. 4. Koo MS, Kim NY, Lee HJ, Yoon SW, Kim KS. Rocuronium-induced neuromuscular block after long pretreatment of clonidine in rabbits. Korean J Anesthesiol. 2010 Sep;59(3):190-5. doi: 10.4097/kjae.2010.59.3.190. Epub 2010 Sep 20. PMID: 20877704; PMCID: PMC2946037.
In vitro protocol:
1. Li J, Gu X, Wan G, Wang Y, Chen K, Chen Q, Lu C. Rocuronium bromide suppresses esophageal cancer via blocking the secretion of C-X-C motif chemokine ligand 12 from cancer associated fibroblasts. J Transl Med. 2023 Apr 8;21(1):248. doi: 10.1186/s12967-023-04081-y. PMID: 37029408; PMCID: PMC10082495. 2. Chompunud Na Ayudhya C, Amponnawarat A, Roy S, Oskeritzian CA, Ali H. MRGPRX2 Activation by Rocuronium: Insights from Studies with Human Skin Mast Cells and Missense Variants. Cells. 2021 Jan 15;10(1):156. doi: 10.3390/cells10010156. PMID: 33467419; PMCID: PMC7830812.
In vivo protocol:
1. Suzuki K, Sunaga H, Yamakawa K, Suga Y, Kondo I, Tsubokawa T, Uezono S. Intravenous infusion of rocuronium bromide prolongs emergence from propofol anesthesia in rats. PLoS One. 2021 Feb 11;16(2):e0246858. doi: 10.1371/journal.pone.0246858. PMID: 33571289; PMCID: PMC7877640. 2. Koo MS, Kim NY, Lee HJ, Yoon SW, Kim KS. Rocuronium-induced neuromuscular block after long pretreatment of clonidine in rabbits. Korean J Anesthesiol. 2010 Sep;59(3):190-5. doi: 10.4097/kjae.2010.59.3.190. Epub 2010 Sep 20. PMID: 20877704; PMCID: PMC2946037.
1: Baine K, Hendrix DV, Kuhn SE, Souza MJ, Jones MP. The Efficacy and Safety of Topical Rocuronium Bromide to Induce Bilateral Mydriasis in Hispaniolan Amazon Parrots ( Amazona ventralis ). J Avian Med Surg. 2016 Mar;30(1):8-13. doi: 10.1647/2015-083. PubMed PMID: 27088739. 2: Prabhakar H, Singh GP, Ali Z, Kalaivani M, Smith MA. Pharmacological and non-pharmacological interventions for reducing rocuronium bromide induced pain on injection in children and adults. Cochrane Database Syst Rev. 2016 Feb 12;2:CD009346. doi: 10.1002/14651858.CD009346.pub2. Review. PubMed PMID: 26871982. 3: Petritz OA, Guzman DS, Gustavsen K, Wiggans KT, Kass PH, Houck E, Murphy CJ, Paul-Murphy J. Evaluation of the mydriatic effects of topical administration of rocuronium bromide in Hispaniolan Amazon parrots (Amazona ventralis). J Am Vet Med Assoc. 2016 Jan 1;248(1):67-71. doi: 10.2460/javma.248.1.67. PubMed PMID: 26684093. 4: Ovezov AM, Karpun NA, Prokoshev PV, Timoshin SS, Lugovoy AV, Bragina SV. [EFFICACY AND SAFETY OF ROCURONIUM BROMIDE PRODUCED IN THE RUSSIAN FEDERATION: A SINGLE-BLIND RANDOMIZED CLINICAL TRIAL]. Anesteziol Reanimatol. 2015 May-Jun;60(3):34-9. Russian. PubMed PMID: 26415294. 5: Koksal PM, Gürbüzel M. Analysis of genotoxic activity of ketamine and rocuronium bromide using the somatic mutation and recombination test in Drosophila melanogaster. Environ Toxicol Pharmacol. 2015 Mar;39(2):628-34. doi: 10.1016/j.etap.2014.12.010. Epub 2014 Dec 27. PubMed PMID: 25682000. 6: Briganti A, Barsotti G, Portela DA, Di Nieri C, Breghi G. Effects of rocuronium bromide on globe position and respiratory function in isoflurane-anesthetized dogs: a comparison between three different dosages. Vet Ophthalmol. 2015 Mar;18(2):89-94. doi: 10.1111/vop.12108. Epub 2013 Oct 17. PubMed PMID: 24131770. 7: Gorynski K, Bojko B, Kluger M, Jerath A, Wąsowicz M, Pawliszyn J. Development of SPME method for concomitant sample preparation of rocuronium bromide and tranexamic acid in plasma. J Pharm Biomed Anal. 2014 Apr;92:183-92. doi: 10.1016/j.jpba.2014.01.026. Epub 2014 Jan 27. PubMed PMID: 24525565. 8: Moreno-Sala A, Ortiz-Martínez R, Valdivia AG, Torres-de-Moreno MG, Martínez A. Use of neuromuscular blockade with rocuronium bromide for intubation in cats. Vet Anaesth Analg. 2013 Jul;40(4):351-8. doi: 10.1111/vaa.12028. Epub 2013 Mar 9. PubMed PMID: 23480130. 9: Gribkov AV, Berezina VV, Sheludiakov AIu, Kravets LIa. [Rocuronium bromide as component of general anaesthesia in patients with traumatic cerebral compression]. Anesteziol Reanimatol. 2013 May-Jun;(3):18-20. Russian. PubMed PMID: 24340990. 10: Barsotti G, Briganti A, Spratte JR, Ceccherelli R, Breghi G. Safety and efficacy of bilateral topical application of rocuronium bromide for mydriasis in European kestrels (Falco tinnunculus). J Avian Med Surg. 2012 Mar;26(1):1-5. PubMed PMID: 22645832. 11: Pape A, Kertscho H, Stein P, Lossen M, Horn O, Kutschker S, Zwissler B, Habler O. Neuromuscular blockade with rocuronium bromide increases the tolerance of acute normovolemic anemia in anesthetized pigs. Eur Surg Res. 2012;48(1):16-25. doi: 10.1159/000333797. Epub 2011 Dec 20. PubMed PMID: 22189343. 12: Maeda T, Enomoto T, Kamiyama Y, Inada E. [Anesthetic management for electroconvulsive therapy using rocuronium bromide and sugammadex sodium in a patient with suspected malignant syndrome]. Masui. 2011 Dec;60(12):1384-6. Japanese. PubMed PMID: 22256579. 13: Kalezić N, Krivić B, Živaljević V, Ugrinović D, Jovanović D, Marković D, Veličković J, Ladjević N. [Characteristics of neuromuscular block after administration of rocuronium bromide in patients with end-stage renal failure]. Srp Arh Celok Lek. 2011 Nov-Dec;139(11-12):765-71. Serbian. PubMed PMID: 22338473. 14: Auer U, Moens Y. Neuromuscular blockade with rocuronium bromide for ophthalmic surgery in horses. Vet Ophthalmol. 2011 Jul;14(4):244-7. doi: 10.1111/j.1463-5224.2010.00870.x. Epub 2011 Apr 18. PubMed PMID: 21733065. 15: Bebawy JF. Rocuronium bromide. Anesthesiology. 2011 Jun;114(6):1486. doi: 10.1097/ALN.0b013e3181fe3cea. PubMed PMID: 21263302. 16: Zan U, Topaktas M, Istifli ES. In vitro genotoxicity of rocuronium bromide in human peripheral lymphocytes. Cytotechnology. 2011 May;63(3):239-45. doi: 10.1007/s10616-011-9334-0. Epub 2011 Jan 21. PubMed PMID: 21253831; PubMed Central PMCID: PMC3081051. 17: Md Shahnawaz M, Shahjahan B, Sarwar SS. Evaluation of intubating conditions after rocuronium bromide in adults induced with propofol or thiopentone sodium. J Anaesthesiol Clin Pharmacol. 2011 Apr;27(2):215-9. doi: 10.4103/0970-9185.81829. PubMed PMID: 21772683; PubMed Central PMCID: PMC3127302. 18: Jang YH, Kim SG, Son YH, Park JM. Rocuronium bromide induced anaphylaxis in a child -A case report-. Korean J Anesthesiol. 2010 Dec;59(6):411-5. doi: 10.4097/kjae.2010.59.6.411. Epub 2010 Dec 31. PubMed PMID: 21253379; PubMed Central PMCID: PMC3022135. 19: Nakanishi T, Nishihama M, Hirai A, Uchikado M, Shimosaka M, Uehara A. [Successful management of a patient with myotonic dystrophy under total intravenous anesthesia with propofol, remifentnil and rocuronium bromide, combined with epidural anesthesia]. Masui. 2010 Nov;59(11):1419-22. Japanese. PubMed PMID: 21077314. 20: Chatrath V, Singh I, Chatrath R, Arora N. Comparison of intubating conditions of rocuronium bromide and vecuronium bromide with succinylcholine using "timing principle". J Anaesthesiol Clin Pharmacol. 2010 Oct;26(4):493-7. PubMed PMID: 21547177; PubMed Central PMCID: PMC3087261.

View History

Bromebrate sodium

Bromebrate sodium