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MedKoo Cat#: 318666 | Name: Rimexolone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rimexolone is a glucocorticoid steroid used to treat inflammation in the eye.

Chemical Structure

Rimexolone
Rimexolone
CAS#49697-38-3

Theoretical Analysis

MedKoo Cat#: 318666

Name: Rimexolone

CAS#: 49697-38-3

Chemical Formula: C24H34O3

Exact Mass: 370.2508

Molecular Weight: 370.53

Elemental Analysis: C, 77.80; H, 9.25; O, 12.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Rimexolone, Org-6216, Rimexel, Vexol
IUPAC/Chemical Name
(8S,9S,10R,11S,13S,14S,16R,17S)-11-hydroxy-10,13,16,17-tetramethyl-17-propionyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key
QTTRZHGPGKRAFB-OOKHYKNYSA-N
InChi Code
InChI=1S/C24H34O3/c1-6-20(27)24(5)14(2)11-18-17-8-7-15-12-16(25)9-10-22(15,3)21(17)19(26)13-23(18,24)4/h9-10,12,14,17-19,21,26H,6-8,11,13H2,1-5H3/t14-,17+,18+,19+,21-,22+,23+,24-/m1/s1
SMILES Code
CCC(=O)[C@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot#S8G06M06
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 370.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Spies CM, Gaber T, Hahne M, Naumann L, Tripmacher R, Schellmann S, Stahn C, Burmester GR, Radbruch A, Buttgereit F. Rimexolone inhibits proliferation, cytokine expression and signal transduction of human CD4+ T-cells. Immunol Lett. 2010 Jun 15;131(1):24-32. doi: 10.1016/j.imlet.2010.03.009. Epub 2010 Apr 2. PubMed PMID: 20363256. 2: Vico-Ruiz E, Benítez-Del-Castillo-Sánchez JM, Cuiña-Sardiña R, Martínez-De-La-Casa JM, García-Sánchez J. [0.1% dexamathasone and 1% rimexolone. A comparative study in the postoperative treatment after cataract extraction]. Arch Soc Esp Oftalmol. 2009 Jun;84(6):299-304. Spanish. PubMed PMID: 19568990. 3: Kavuncu S, Horoz H, Ardagil A, Erbil HH. Rimexolone 1% versus prednisolone acetate in preventing early postoperative inflammation after cataract surgery. Int Ophthalmol. 2008 Aug;28(4):281-5. Epub 2007 Aug 31. PubMed PMID: 17762913. 4: Florea A, Zwart JE, Lee CW, Depew A, Park SK, Inman J, Wareham R, Johnson K, John E, Wall GM, Jung T. Effect of topical dexamethasone versus rimexolone on middle ear inflammation in experimental otitis media with effusion. Acta Otolaryngol. 2006 Sep;126(9):910-5. PubMed PMID: 16864486. 5: Hirneiss C, Neubauer AS, Kampik A, Schönfeld CL. Comparison of prednisolone 1%, rimexolone 1% and ketorolac tromethamine 0.5% after cataract extraction: a prospective, randomized, double-masked study. Graefes Arch Clin Exp Ophthalmol. 2005 Aug;243(8):768-73. Epub 2005 Mar 9. PubMed PMID: 15756571. 6: Yaylali V, Ozbay D, Tatlipinar S, Yildirim C, Ozden S. Efficacy and safety of rimexolone 1% versus prednisolone acetate 1% in the control of postoperative inflammation following phacoemulsification cataract surgery. Int Ophthalmol. 2004 Jan;25(1):65-8. PubMed PMID: 15085979. 7: Conrow RE. Synthesis of the 16alpha,17alpha,21-Trimethyl Corticosteroid Rimexolone from Prednisolone. J Org Chem. 1999 Feb 5;64(3):1042-1044. PubMed PMID: 11674186. 8: Solomon KD, Vroman DT, Barker D, Gehlken J. Comparison of ketorolac tromethamine 0.5% and rimexolone 1% to control inflammation after cataract extraction. Prospective randomized double-masked study. J Cataract Refract Surg. 2001 Aug;27(8):1232-7. PubMed PMID: 11524195. 9: Hew KW, Carson DL, Siglin JC. Reproductive toxicity studies in rats with rimexolone, a corticoid ophthalmic suspension. Toxicol Sci. 1999 Oct;51(2):280-8. PubMed PMID: 10543030. 10: Assil KK, Massry G, Lehmann R, Fox K, Stewart R. Control of ocular inflammation after cataract extraction with rimexolone 1% ophthalmic suspension. J Cataract Refract Surg. 1997 Jun;23(5):750-7. PubMed PMID: 9278798. 11: van Vliet-Daskalopoulou E, Jentjens T, Scheffer RT. Intra-articular rimexolone in the rheumatoid knee: a placebo-controlled, double-blind, multicentre trial of three doses. Br J Rheumatol. 1987 Dec;26(6):450-3. PubMed PMID: 3318993. 12: Lewis AJ. The local anti-inflammatory activity of rimexolone (Org 6216) in fibrin-induced monoarticular arthritis and adjuvant-induced arthritis. Agents Actions. 1980 Jun;10(3):258-65. PubMed PMID: 7405753. 13: Arellanes-García L, Padilla-Aguilar G, Navarro-López P, Espinoza-Martínez C. [Efficacy of prednisolone and rimexolone in HLA-B27 positive patients with acute anterior uveitis]. Gac Med Mex. 2005 Sep-Oct;141(5):363-6. Spanish. PubMed PMID: 16353881. 14: Biswas J, Ganeshbabu TM, Raghavendran SR, Raizada S, Mondkar SV, Madhavan HN. Efficacy and safety of 1% rimexolone versus 1% prednisolone acetate in the treatment of anterior uveitis--a randomized triple masked study. Int Ophthalmol. 2004 May;25(3):147-53. PubMed PMID: 15847313. 15: Fan DS, Yu CB, Chiu TY, Wong CY, Ng JS, Pang CP, Lam DS. Ocular-hypertensive and anti-inflammatory response to rimexolone therapy in children. Arch Ophthalmol. 2003 Dec;121(12):1716-21. PubMed PMID: 14662591. 16: Cazabon S, Morrell AJ. Rimexolone-induced intraocular pressure elevation. Eye (Lond). 2001 Oct;15(Pt 5):663-4. Review. PubMed PMID: 11702986. 17: Bron A, Denis P, Hoang-Xuan TC, Boureau-Andrieux C, Crozafon P, Hachet E, Medhorn E, Akingbehin A. The effects of Rimexolone 1% in postoperative inflammation after cataract extraction. A double-masked placebo-controlled study. Eur J Ophthalmol. 1998 Jan-Mar;8(1):16-21. PubMed PMID: 9590590. 18: Halpern MT, Palmer CS, Foster S, Pal A, Battista C. A pharmacoeconomic analysis of rimexolone for the treatment of ophthalmic inflammatory conditions. Am J Manag Care. 1998 Jun;4(6):854-62. PubMed PMID: 10181071. 19: Leibowitz HM, Bartlett JD, Rich R, McQuirter H, Stewart R, Assil K. Intraocular pressure-raising potential of 1.0% rimexolone in patients responding to corticosteroids. Arch Ophthalmol. 1996 Aug;114(8):933-7. PubMed PMID: 8694727. 20: Foster CS, Alter G, DeBarge LR, Raizman MB, Crabb JL, Santos CI, Feiler LS, Friedlaender MH. Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis. Am J Ophthalmol. 1996 Aug;122(2):171-82. PubMed PMID: 8694085.