Synonym
BRN 5857899; BRN5857899; BRN-5857899; Terfenadine; Seldane; Terfen
IUPAC/Chemical Name
1-(4-(tert-butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butan-1-ol
InChi Key
GUGOEEXESWIERI-UHFFFAOYSA-N
InChi Code
InChI=1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3
SMILES Code
OC(C1=CC=C(C(C)(C)C)C=C1)CCCN2CCC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)CC2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
471.69
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Chen C. Some pharmacokinetic aspects of the lipophilic terfenadine and zwitterionic fexofenadine in humans. Drugs R D. 2007;8(5):301-14. Review. PubMed PMID: 17767395.
2: Rufke C, Nieber K. [Long QT interval. Interaction of terfenadine and itraconazole]. Med Monatsschr Pharm. 2006 Jan;29(1):22-4. Review. German. PubMed PMID: 16463550.
3: van den Anker JN, de Wildt SN. [Excessive terfenadine level due to drinking grapefruit juice]. Ned Tijdschr Geneeskd. 1997 Oct 11;141(41):1976-8. Review. Dutch. PubMed PMID: 9550749.
4: Endre L, Mezei G, Kósa L, Börzsönyi L, Cserháti E. [Multicenter studies of terfenadine-containing suspensions in children with hayfever]. Orv Hetil. 1998 Jan 4;139(1):11-5. Review. Hungarian. PubMed PMID: 9454105.
5: Ishizaki T. Strategic proposals to avoid drug interactions during drug development: a lesson from a terfenadine-related drug interaction. J Toxicol Sci. 1996 Dec;21(5):301-3. Review. PubMed PMID: 9035041.
6: Paris DG, Parente TF, Bruschetta HR, Guzman E, Niarchos AP. Torsades de pointes induced by erythromycin and terfenadine. Am J Emerg Med. 1994 Nov;12(6):636-8. Review. PubMed PMID: 7945604.
7: Kivistö KT, Neuvonen PJ, Klotz U. Inhibition of terfenadine metabolism. Pharmacokinetic and pharmacodynamic consequences. Clin Pharmacokinet. 1994 Jul;27(1):1-5. Review. PubMed PMID: 7955768.
8: Zhang MQ, Timmerman H. Terfenadine: a mixture of equipotent antihistamine enantiomers without a clear 'isomeric ballast'. Pharm World Sci. 1993 Oct 15;15(5):186-92. Review. PubMed PMID: 8257954.
9: Aaronson DW. Effects of terfenadine on psychomotor performance. An overview. Drug Saf. 1993 Apr;8(4):321-9. Review. PubMed PMID: 8481218.
10: Jankowski R, Wagenmann M, Baroody FM, Naclerio R. Effect of terfenadine on nasal provocation. Int Arch Allergy Immunol. 1993;101(3):311-7. Review. PubMed PMID: 8324394.
11: Masheter HC. Terfenadine. The first nonsedating antihistamine. Clin Rev Allergy. 1993 Spring;11(1):5-34. Review. PubMed PMID: 8319161.
12: Pohjola-Sintonen S. [Treatment with terfenadine and ketoconazole or itraconazole can cause torsades de pointes ventricular tachycardia]. Duodecim. 1993;109(2):164-6. Review. Finnish. PubMed PMID: 8013320.
13: Wynn RL. Erythromycin and ketoconazole (Nizoral) associated with terfenadine (Seldane)-induced ventricular arrhythmias. Gen Dent. 1993 Jan-Feb;41(1):27-9. Review. PubMed PMID: 7489857.
14: Cortese LM, Bjornson DC. Comment: the new macrolide antibiotics and terfenadine. Ann Pharmacother. 1992 Jul-Aug;26(7-8):1019. Review. PubMed PMID: 1504390.
15: Ciprandi G, Iudice A, Tosca MA, Ruffoni S, Buscaglia S, Canonica GW. Comparative effects of terfenadine and loratadine in the treatment of hay fever. J Investig Allergol Clin Immunol. 1991 Dec;1(6):368-72. Review. PubMed PMID: 1669595.
16: McTavish D, Goa KL, Ferrill M. Terfenadine. An updated review of its pharmacological properties and therapeutic efficacy. Drugs. 1990 Apr;39(4):552-74. Review. PubMed PMID: 1972050.
17: Brooks CD, Karl KJ, Francom SF. Profile of ragweed hay fever symptom control with terfenadine started before or after symptoms are established. Clin Exp Allergy. 1990 Jan;20(1):21-6. Review. PubMed PMID: 2107013.
18: Carter CA, Wojciechowski NJ, Hayes JM, Skoutakis VA, Rickman LA. Terfenadine, a nonsedating antihistamine. Drug Intell Clin Pharm. 1985 Nov;19(11):812-7. Review. PubMed PMID: 2866079.
19: Sorkin EM, Heel RC. Terfenadine. A review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1985 Jan;29(1):34-56. Review. PubMed PMID: 2857636.
