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MedKoo Cat#: 522706 | Name: TCS-5861528
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TCS-5861528, also known as Chembridge-5861528, is a TRPA1 receptor antagonist. TCS-5861528 antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively). TRPA1 was found to mediate acute inflammation and the development of degenerative cartilage changes and joint pain in MIA-induced experimental OA in the mouse. TRPA1 may be a potential mediator and drug target in OA.

Chemical Structure

TCS-5861528
TCS-5861528
CAS#332117-28-9

Theoretical Analysis

MedKoo Cat#: 522706

Name: TCS-5861528

CAS#: 332117-28-9

Chemical Formula: C19H23N5O3

Exact Mass: 369.1801

Molecular Weight: 369.43

Elemental Analysis: C, 61.77; H, 6.28; N, 18.96; O, 12.99

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 550.00 2 Weeks
50mg USD 800.00 2 Weeks
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Synonym
TCS5861528, TCS-5861528, TCS 5861528, Chembridge-5861528, Chembridge5861528, Chembridge 5861528
IUPAC/Chemical Name
2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide
InChi Key
ZUTUWJYMCADJHD-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H23N5O3/c1-5-12(2)13-6-8-14(9-7-13)21-15(25)10-24-11-20-17-16(24)18(26)23(4)19(27)22(17)3/h6-9,11-12H,5,10H2,1-4H3,(H,21,25)
SMILES Code
O=C(NC1=CC=C(C(C)CC)C=C1)CN2C=NC(N(C)C(N3C)=O)=C2C3=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 369.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu Y, Chen AW, Goodnough CL, Lu Y, Zhang Y, Gross ER. IcyHot analgesic topical cream limits cardiac injury in rodents. Transl Res. 2021 Jan;227:42-52. doi: 10.1016/j.trsl.2020.06.009. Epub 2020 Jul 3. PMID: 32629175; PMCID: PMC7719099. 2: Moilanen LJ, Hämäläinen M, Ilmarinen P, Kankaanranta H, Nieminen RM, Moilanen E, Lehtimäki L. Transient Receptor Potential Ankyrin 1 Enhances Ovalbumin- Induced Acute Allergic Inflammation in Murine Models. Int Arch Allergy Immunol. 2019;178(3):238-247. doi: 10.1159/000494932. Epub 2019 Jan 30. PMID: 30699406. 3: Wang Z, Xu Y, Wang M, Ye J, Liu J, Jiang H, Ye D, Wan J. TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice. EBioMedicine. 2018 Oct;36:54-62. doi: 10.1016/j.ebiom.2018.08.022. Epub 2018 Oct 5. Erratum in: EBioMedicine. 2018 Dec;38:292. doi: 10.1016/j.ebiom.2018.11.006. PMID: 30297144; PMCID: PMC6197736. 4: Moilanen LJ, Hämäläinen M, Nummenmaa E, Ilmarinen P, Vuolteenaho K, Nieminen RM, Lehtimäki L, Moilanen E. Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis. Osteoarthritis Cartilage. 2015 Nov;23(11):2017-26. doi: 10.1016/j.joca.2015.09.008. PMID: 26521748. 5: Shatillo A, Koroleva K, Giniatullina R, Naumenko N, Slastnikova AA, Aliev RR, Bart G, Atalay M, Gu C, Khazipov R, Davletov B, Grohn O, Giniatullin R. Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system. Neuroscience. 2013 Dec 3;253:341-9. doi: 10.1016/j.neuroscience.2013.09.002. Epub 2013 Sep 11. PMID: 24036374. 6: Fernandes ES, Vong CT, Quek S, Cheong J, Awal S, Gentry C, Aubdool AA, Liang L, Bodkin JV, Bevan S, Heads R, Brain SD. Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B₄-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1. FASEB J. 2013 Apr;27(4):1664-73. doi: 10.1096/fj.12-221218. Epub 2012 Dec 27. PMID: 23271050. 7: Vermeulen W, De Man JG, De Schepper HU, Bult H, Moreels TG, Pelckmans PA, De Winter BY. Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats. Eur J Pharmacol. 2013 Jan 5;698(1-3):404-12. doi: 10.1016/j.ejphar.2012.10.014. Epub 2012 Oct 23. PMID: 23099257.

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