Proparacaine Hydrochloride | CAS# 5875-06-9

MedKoo Cat#: 318585 | Name: Proparacaine Hydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. It is used as a topical ophthalmic anesthetic. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.

Chemical Structure

Proparacaine Hydrochloride

CAS# 5875-06-9

Theoretical Analysis

MedKoo Cat#: 318585

Name: Proparacaine Hydrochloride

CAS#: 5875-06-9

Chemical Formula: C16H27ClN2O3

Exact Mass: 0.0000

Molecular Weight: 330.85

Elemental Analysis: C, 58.08; H, 8.23; Cl, 10.72; N, 8.47; O, 14.51

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 150.00
200mg	USD 250.00
500mg	USD 450.00
1g	USD 650.00
2g	USD 950.00

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Synonym

Proparacaine Hydrochloride; Proxymetacaine hydrochloride; Proparacaine Hcl; Ophthain; proxymetacaine monohydrochloride; UNII-U96OL57GOY; Minims; Proxymetacaine Hydrochloride; Ocu-Caine; Ophthaine; Ophthetic; Parcaine;

IUPAC/Chemical Name

2-(diethylamino)ethyl 3-amino-4-propoxybenzoate;hydrochloride

InChi Key

BFUUJUGQJUTPAF-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H

SMILES Code

CCCOC1=C(C=C(C=C1)C(=O)OCCN(CC)CC)N.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 330.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Gonzalez VH, Uram M, Schupp A, Widmann M, Novack GD. AG-920 (Articaine) Ophthalmic Solution: A Masked, Active-Controlled Evaluation of Its Local Anesthetic Efficacy and Safety in Pediatric Patients. J Ocul Pharmacol Ther. 2024 Jun;40(5):293-296. doi: 10.1089/jop.2023.0187. Epub 2024 Apr 22. PMID: 38647654. 2: Zhou A, Rabljenovic A, Steinemann TL. Proparacaine Overuse in Corneal Abrasions at the Emergency Department: A Case Series. Eye Contact Lens. 2024 Jun 1;50(6):274-275. doi: 10.1097/ICL.0000000000001083. Epub 2024 Mar 13. PMID: 38477795. 3: Mahan M, Flor R, Purt B. Local and Regional Anesthesia in Ophthalmology and Ocular Trauma. 2023 May 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 34662068. 4: Ma X, Liang Q, Xue S, Ren Q, Du Q, Zhang Z, Li X, Liu X, Gao Y, Li J. EFFECT OF ANESTHESIA DURATION ON INTRAVITREAL INJECTION PAIN: A double-blinded, randomized, comparative study. Retina. 2023 Aug 1;43(8):1386-1392. doi: 10.1097/IAE.0000000000003824. PMID: 37130433. 5: Mahajan A, Coelho A, Pissurlenkar R, Fernandes A, Tagalpallewar A. Prediction of Ocular Toxicity of Potential Degradation Products of Proparacaine Hydrochloride Subjected under ICH Recommended Stress Conditions. J Chromatogr Sci. 2023 Apr 24;61(4):393-401. doi: 10.1093/chromsci/bmac039. PMID: 35543315. 6: Kyei S, Abaka Dadzie NY, Zaabaar E, Asamoah Dwomoh KA, Asiedu K. Age and Sex Variation in the Duration of Action and Corneal Touch Threshold (CTT) following Instillation of 0.5% Topical Ophthalmic Proparacaine and Tetracaine Hydrochlorides. J Ophthalmol. 2021 Jul 14;2021:8661098. doi: 10.1155/2021/8661098. PMID: 34336260; PMCID: PMC8294970. 7: Taleb A, Zhou YP, Meng LT, Zhu MY, Zhang Q, Naveed M, Li LD, Wang P, Zhou QG, Meng F, Han F. New application of an old drug proparacaine in treating epilepsy via liposomal hydrogel formulation. Pharmacol Res. 2021 Jul;169:105636. doi: 10.1016/j.phrs.2021.105636. Epub 2021 Apr 29. PMID: 33932606. 8: Lelescu CA, Dumitras DA, Iurian S, Staffieri F, Muresan C. Effects of topical application of tramadol with/without dexmedetomidine and proparacaine on corneal sensitivity in rats. Int Ophthalmol. 2021 Feb;41(2):465-473. doi: 10.1007/s10792-020-01596-x. Epub 2020 Oct 23. PMID: 33095346. 9: Yang Z, Zhao J, Feng Y, Lei Y, Liu D, Qin F, Zheng J, Wang S. Identification, synthesis and structural confirmation of process-related impurities in proparacaine hydrochloride. J Pharm Biomed Anal. 2020 Oct 25;190:113497. doi: 10.1016/j.jpba.2020.113497. Epub 2020 Jul 29. PMID: 32798917. 10: Khokhar S, Gupta Y, Dhull C, Singh V. Intraoperative aberrometry in cataract surgery with topical versus peribulbar anesthesia. Indian J Ophthalmol. 2020 May;68(5):776-779. doi: 10.4103/ijo.IJO_913_19. PMID: 32317444; PMCID: PMC7350467. 11: Kovaļčuka L, Mūrniece G. Normal reference ranges of ocular physiology and sonographic biometry of Latvian Hunting dogs. Vet World. 2019 Apr;13(4):807-811. doi: 10.14202/vetworld.2020.807-811. Epub 2020 Apr 28. PMID: 32546930; PMCID: PMC7245716. 12: Fentiman KE, Rankin AJ, Meekins JM, Roush JK. Effects of topical ophthalmic application of 0.5% proparacaine hydrochloride on aerobic bacterial culture results for naturally occurring infected corneal ulcers in dogs. J Am Vet Med Assoc. 2018 Nov 1;253(9):1140-1145. doi: 10.2460/javma.253.9.1140. PMID: 30311533. 13: Hanssens JM, Quintana-Giraldo C, Jacques S, El-Zoghbi N, Lampasona V, Langevin C, Bouchard JF. Shelf Life and Efficacy of Diagnostic Eye Drops. Optom Vis Sci. 2018 Oct;95(10):947-952. doi: 10.1097/OPX.0000000000001288. PMID: 30234830. 14: Kleris RS, Keswani A, Lugar P. The Eyes Have It: Eyelid Swelling and Rash in a 79-year-old Woman With Macular Degeneration. Allergy Rhinol (Providence). 2018 May 1;9:2152656718763385. doi: 10.1177/2152656718763385. PMID: 29977647; PMCID: PMC6028157. 15: Chaudhary RA, Khaqan HA, Ahmad A, Imtiaz U, Raza H, Shabbir U. Comparison of Topical Versus Peribulbar Anesthesia for 23G Pars Plana Vitrectomy. J Coll Physicians Surg Pak. 2018 Jun;28(6):452-455. doi: 10.29271/jcpsp.2018.06.452. PMID: 29848422. 16: Altınsoy F, Alver O, Doğanay S. A Rare Case of Blebharitis: Phthiriasis Palpebrarum. Turkiye Parazitol Derg. 2018 Mar;42(1):90-92. doi: 10.5152/tpd.2018.4824. PMID: 29780020. 17: Venturi F, Blocker T, Dees DD, Madsen R, Brinkis J. Corneal anesthetic effect and ocular tolerance of 3.5% lidocaine gel in comparison with 0.5% aqueous proparacaine and 0.5% viscous tetracaine in normal canines. Vet Ophthalmol. 2017 Sep;20(5):405-410. doi: 10.1111/vop.12440. Epub 2016 Dec 15. PMID: 27981712. 18: Takkar B, Sharma P, Gaur N, Singh AK, Ramachandran R. Proparacaine-Induced Mydriasis During Strabismus Surgery. Semin Ophthalmol. 2018;33(3):367-370. doi: 10.1080/08820538.2016.1247178. Epub 2016 Dec 14. PMID: 27960641. 19: Little E, Yvorchuk-St Jean K, Little W, Sithole F, St Jean G. Degree of corneal anesthesia after topical application of 0.4% oxybuprocaine ophthalmic solution in normal equids. Can J Vet Res. 2016 Oct;80(4):329-334. PMID: 27733789; PMCID: PMC5052886. 20: Little WB, Jean GS, Sithole F, Little E, Jean KY. Degree of corneal anaesthesia after topical application of 0.4% oxybuprocaine hydrochloride and 0.5% proparacaine hydrochloride ophthalmic solution in clinically normal cattle. Aust Vet J. 2016 Jun;94(6):181-5. doi: 10.1111/avj.12443. PMID: 27237118.