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MedKoo Cat#: 318579 | Name: Progesterone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Progesterone is the biosynthetic precursor of all other steroid hormones. Progesterone induces maturation and secretory activity of the uterine endothelium while suppressing ovulation. Progesterone is implicated in the etiology of breast cancer. Progesterone is an activator of Progesterone Receptor. It is a C-21 steroid hormone.

Chemical Structure

Progesterone
Progesterone
CAS#57-83-0

Theoretical Analysis

MedKoo Cat#: 318579

Name: Progesterone

CAS#: 57-83-0

Chemical Formula: C21H30O2

Exact Mass: 314.2246

Molecular Weight: 314.46

Elemental Analysis: C, 80.21; H, 9.62; O, 10.18

Price and Availability

Size Price Availability Quantity
2g USD 350.00 2 Weeks
5g USD 550.00 2 Weeks
10g USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Progesterone; Agolutin; Crinone; Luteohormone; Utrogestan; Cyclogest; Progesterone, (13 alpha,17 alpha)-(+-)-Isomer; Progesterone, (17 alpha)-Isomer; Progesterone, (9 beta,10 alpha)-Isomer; Hormoflaveine; Lutociclina;
IUPAC/Chemical Name
(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
InChi Key
RJKFOVLPORLFTN-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3
SMILES Code
CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 314.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Roney JR, Simmons ZL. Within-cycle fluctuations in progesterone negatively predict changes in both in-pair and extra-pair desire among partnered women. Horm Behav. 2016 Apr 2. pii: S0018-506X(16)30015-0. doi: 10.1016/j.yhbeh.2016.03.008. [Epub ahead of print] PubMed PMID: 27049465. 2: Arbo BD, Benetti F, Ribeiro MF. Astrocytes as a target for neuroprotection: modulation by progesterone and dehydroepiandrosterone. Prog Neurobiol. 2016 Apr 2. pii: S0301-0082(15)30050-2. doi: 10.1016/j.pneurobio.2016.03.010. [Epub ahead of print] Review. PubMed PMID: 27048624. 3: Fox NS, Gupta S, Lam-Rachlin J, Rebarber A, Klauser CK, Saltzman DH. Cervical Pessary and Vaginal Progesterone in Twin Pregnancies With a Short Cervix. Obstet Gynecol. 2016 Apr;127(4):625-30. doi: 10.1097/AOG.0000000000001300. PubMed PMID: 26959202. 4: Alvarado-Espino AS, Meza-Herrera CA, Carrillo E, González-Álvarez VH, Guillen-Muñoz JM, Ángel-García O, Mellado M, Véliz-Deras FG. Reproductive outcomes of Alpine goats primed with progesterone and treated with human chorionic gonadotropin during the anestrus-to-estrus transition season. Anim Reprod Sci. 2016 Apr;167:133-8. doi: 10.1016/j.anireprosci.2016.02.019. Epub 2016 Feb 22. PubMed PMID: 26944772. 5: Sangster JL, Ali JM, Snow DD, Kolok AS, Bartelt-Hunt SL. Bioavailability and Fate of Sediment-Associated Progesterone in Aquatic Systems. Environ Sci Technol. 2016 Apr 5;50(7):4027-36. doi: 10.1021/acs.est.5b06082. Epub 2016 Mar 17. PubMed PMID: 26938708. 6: Rossier NM, Chew G, Zhang K, Riva F, Fent K. Activity of binary mixtures of drospirenone with progesterone and 17α-ethinylestradiol in vitro and in vivo. Aquat Toxicol. 2016 May;174:109-22. doi: 10.1016/j.aquatox.2016.02.005. Epub 2016 Feb 22. PubMed PMID: 26930480. 7: Stevenson JS, Pulley SL. Feedback effects of estradiol and progesterone on ovulation and fertility of dairy cows after gonadotropin-releasing hormone-induced release of luteinizing hormone. J Dairy Sci. 2016 Apr;99(4):3003-15. doi: 10.3168/jds.2015-10091. Epub 2016 Feb 19. PubMed PMID: 26898279. 8: Kawprasertsri S, Pietras RJ, Marquez-Garban DC, Boonyaratanakornkit V. Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. Cancer Lett. 2016 May 1;374(2):279-91. doi: 10.1016/j.canlet.2016.02.014. Epub 2016 Feb 15. PubMed PMID: 26892043. 9: Yan L, Robinson R, Shi Z, Mann G. Efficacy of progesterone supplementation during early pregnancy in cows: A meta-analysis. Theriogenology. 2016 May;85(8):1390-1398.e1. doi: 10.1016/j.theriogenology.2015.12.027. Epub 2015 Dec 31. PubMed PMID: 26822872. 10: Casper RF, Yanushpolsky EH. Optimal endometrial preparation for frozen embryo transfer cycles: window of implantation and progesterone support. Fertil Steril. 2016 Apr;105(4):867-72. doi: 10.1016/j.fertnstert.2016.01.006. Epub 2016 Jan 25. Review. PubMed PMID: 26820769. 11: Ginther OJ, Baldrighi JM, Castro T, Wolf CA, Santos VG. Concentrations of progesterone, a metabolite of PGF2α, prolactin, and luteinizing hormone during development of idiopathic persistent corpus luteum in mares. Domest Anim Endocrinol. 2016 Apr;55:114-22. doi: 10.1016/j.domaniend.2015.12.004. Epub 2015 Dec 28. PubMed PMID: 26808976. 12: Kowalik MK, Martyniak M, Rekawiecki R, Kotwica J. Expression and immunolocalization of membrane progesterone receptors in the bovine oviduct. Domest Anim Endocrinol. 2016 Apr;55:83-96. doi: 10.1016/j.domaniend.2015.12.001. Epub 2015 Dec 17. PubMed PMID: 26774557. 13: Pugliesi G, Santos FB, Lopes E, Nogueira É, Maio JR, Binelli M. Improved fertility in suckled beef cows ovulating large follicles or supplemented with long-acting progesterone after timed-AI. Theriogenology. 2016 Apr 15;85(7):1239-48. doi: 10.1016/j.theriogenology.2015.12.006. Epub 2015 Dec 18. PubMed PMID: 26764150. 14: Nakamura R, Yamamoto N, Shiina N, Miyaki T, Ikebe D, Itami M, Shida T, Miyazaki M. Impact of host and histopathological factors on the discrepancies in estrogen receptor, and progesterone receptor, and HER2 status between core needle biopsy and surgically excised tumors. Breast. 2016 Apr;26:141-7. doi: 10.1016/j.breast.2015.10.009. Epub 2015 Dec 28. PubMed PMID: 26732051. 15: Pabuccu EG, Pabuccu R, Evliyaoglu Ozdegirmenci O, Bostancı Durmus A, Keskin M. Combined progesterone (IM + V) versus vaginal progesterone for luteal support in cleavage-stage embryo transfer cycles of good prognosis patients. Gynecol Endocrinol. 2016 May;32(5):366-9. doi: 10.3109/09513590.2015.1127910. Epub 2016 Jan 6. PubMed PMID: 26732029. 16: Demir B, Kahyaoglu I, Guvenir A, Yerebasmaz N, Altinbas S, Dilbaz B, Dilbaz S, Mollamahmutoglu L. Progesterone change in the late follicular phase affects pregnancy rates both agonist and antagonist protocols in normoresponders: a case-controlled study in ICSI cycles. Gynecol Endocrinol. 2016 May;32(5):361-5. doi: 10.3109/09513590.2015.1121226. Epub 2015 Dec 10. PubMed PMID: 26654315. 17: Reyes H. Sulfated progesterone metabolites in the pathogenesis of intrahepatic cholestasis of pregnancy: Another loop in the ascending spiral of medical knowledge. Hepatology. 2016 Apr;63(4):1080-2. doi: 10.1002/hep.28365. Epub 2016 Jan 14. PubMed PMID: 26599133. 18: Abu-Hayyeh S, Ovadia C, Lieu T, Jensen DD, Chambers J, Dixon PH, Lövgren-Sandblom A, Bolier R, Tolenaars D, Kremer AE, Syngelaki A, Noori M, Williams D, Marin JJ, Monte MJ, Nicolaides KH, Beuers U, Oude-Elferink R, Seed PT, Chappell L, Marschall HU, Bunnett NW, Williamson C. Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum. Hepatology. 2016 Apr;63(4):1287-98. doi: 10.1002/hep.28265. Epub 2015 Dec 28. PubMed PMID: 26426865. 19: Senol S, Sayar I, Ceyran AB, Ibiloglu I, Akalin I, Firat U, Kosemetin D, Engin Zerk P, Aydin A. Stromal Clues in Endometrial Carcinoma: Loss of Expression of β-Catenin, Epithelial-Mesenchymal Transition Regulators, and Estrogen-Progesterone Receptor. Int J Gynecol Pathol. 2016 May;35(3):238-248. PubMed PMID: 26367784. 20: He S, Allen JC, Malhotra R, Østbye T, Tan TC. Association of maternal serum progesterone in early pregnancy with low birth weight and other adverse pregnancy outcomes. J Matern Fetal Neonatal Med. 2016 Jun;29(12):1999-2004. doi: 10.3109/14767058.2015.1072159. Epub 2015 Aug 28. PubMed PMID: 26335272.