MedKoo Cat#: 318576 | Name: Procyclidine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Procyclidine hydrochloride is a muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in Parkinsonism.

Chemical Structure

Procyclidine HCl
Procyclidine HCl
CAS#1508-76-5

Theoretical Analysis

MedKoo Cat#: 318576

Name: Procyclidine HCl

CAS#: 1508-76-5

Chemical Formula: C19H30ClNO

Exact Mass: 0.0000

Molecular Weight: 323.90

Elemental Analysis: C, 70.45; H, 9.34; Cl, 10.95; N, 4.32; O, 4.94

Price and Availability

Size Price Availability Quantity
200mg USD 250.00 2 Weeks
500mg USD 450.00 2 Weeks
1g USD 750.00 2 Weeks
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Synonym
Procyclidine Hydrochloride; Procyclidine HCl; Tricyclamol hydrochloride; (-)-Tricyclamol iodide; C19H29NO.HCl; Procyclidine Hydrochloride; Rosemont Brand of Procyclidine Hydrochloride; Tricyclamol; Wellcome Brand of Procyclidine Hydrochloride;
IUPAC/Chemical Name
1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;hydrochloride
InChi Key
ZFSPFXJSEHCTTR-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H29NO.ClH/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20;/h1,3-4,9-10,18,21H,2,5-8,11-16H2;1H
SMILES Code
C1CCC(CC1)C(CCN2CCCC2)(C3=CC=CC=C3)O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 323.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Campbell MJ, Demetriou B, Jones R. Assay of procyclidine hydrochloride, cyclizine hydrochloride and diethylcarbamazine citrate in tablets using ion-responsive electrodes. Analyst. 1980 Jun;105(1251):605-11. PubMed PMID: 7416480. 2: Camerman N, Camerman A. The stereochemical basis of anticonvulsant drug action. 3. The structure of procyclidine hydrochloride. Mol Pharmacol. 1971 Jul;7(4):406-12. PubMed PMID: 5113235. 3: RENZI AA, MILCH LJ. Effectiveness of procyclidine hydrochloride (kemadrin) and cycrimine hydrochloride (pagitane) in the prevention of airsickness. J Aviat Med. 1958 Aug;29(8):587-9. PubMed PMID: 13575361. 4: ZIER A, DOSHAY LJ. Procyclidine hydrochloride (kemadrin) treatment of parkinsonism; result in 108 patients. Neurology. 1957 Jul;7(7):485-9. PubMed PMID: 13451881. 5: Schjelderup L, Harbitz O, Groth P, Aasen AJ. Syntheses of (S)-(+)-trihexyphenidyl hydrochloride and (S)-(+)-procyclidine hydrochloride, two anticholinergics, using (S)-(-)-3-cyclohexyl-3-hydroxy-3-phenylpropanoic acid as chiral synthon. Acta Chem Scand B. 1987 May;41(5):356-61. PubMed PMID: 3673449. 6: Meier V. [Poisoning with procyclidine hydrochloride (Kemadrin)]. Schweiz Rundsch Med Prax. 1973 Apr 10;62(15):473-5. German. PubMed PMID: 4695200. 7: Vas CJ, Exley KA, Parsonage MJ. Activation of the EEG by procyclidine hydrochloride in temporal lobe epilepsy. Epilepsia. 1967 Dec;8(4):241-51. PubMed PMID: 5238716. 8: Vas CJ, Exley KA, Parsonage MJ. EEG activation by procyclidine hydrochloride in temporal lobe epilepsy. Electroencephalogr Clin Neurophysiol. 1967 Apr;22(4):395. PubMed PMID: 4164765. 9: GROSS H, LANGNER E. [Prophylaxis and therapy of a drug-related Parkinson syndrome with procyclidine hydrochloride (Kemadrin)]. Wien Klin Wochenschr. 1962 Aug 31;74:569-70. German. PubMed PMID: 13902214.