MedKoo Cat#: 523126 | Name: CW 008

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CW 008 is a cAMP/PKA/CREB pathway activator. It promotes osteogenic differentiation of human bone marrow-derived MSCs in vitro and also increases bone mass and bone volume density in ovariectomized mice.

Chemical Structure

CW 008
CW 008
CAS#1134613-19-6

Theoretical Analysis

MedKoo Cat#: 523126

Name: CW 008

CAS#: 1134613-19-6

Chemical Formula: C21H14F2N6O2

Exact Mass: 420.1146

Molecular Weight: 420.38

Elemental Analysis: C, 60.00; H, 3.36; F, 9.04; N, 19.99; O, 7.61

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
CW 008; CW008; CW-008.
IUPAC/Chemical Name
4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide
InChi Key
KCIMKTNQCUDTFI-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H14F2N6O2/c1-31-13-6-7-29-17(8-13)15(10-24-29)18-16(23)9-14-19(25-18)27-28-20(14)26-21(30)11-2-4-12(22)5-3-11/h2-10H,1H3,(H2,25,26,27,28,30)
SMILES Code
O=C(NC1=NNC2=NC(C3=C4C=C(OC)C=CN4N=C3)=C(F)C=C21)C5=CC=C(F)C=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 420.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kim JM, Choi JS, Kim YH, Jin SH, Lim S, Jang HJ, Kim KT, Ryu SH, Suh PG. An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J Cell Physiol. 2013 Mar;228(3):617-26. doi: 10.1002/jcp.24171. PubMed PMID: 22886506.