CYM5520 is a pyrrolyl ketone derivative that acts as a potent, selective, allosteric agonist of sphingosine-1-phosphate receptor 2 (S1PR2; EC50 = 480 nM) that does not replace native ligand and its binding is not competitive with JTE-013. The compound CYM-5520 does not show any agonsit activity towards S1PR1, S1PR3, S1PR4 or S1PR5. It acts as a full agonist for both wild type and triple mutant S1PR2 (EC50 = 1.6 and 1.5 µM, respectively).
MedKoo Cat#: 523122
Name: CYM5520
CAS#: 1449747-00-5
Chemical Formula: C21H19N3O2
Exact Mass: 345.1477
Molecular Weight: 345.40
Elemental Analysis: C, 73.03; H, 5.54; N, 12.17; O, 9.26
The following data is based on the product molecular weight 345.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
