MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 318790 | Name: Tamsulosin
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tamsulosin is an α1a adrenergic receptor antagonist used in the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin is used in the treatment of difficult urination, a common symptom of enlarged prostate. Tamsulosin, and other medications in the class called alpha blockers, work by relaxing bladder neck muscles and muscle fibers in the prostate itself and make it easier to urinate.

Chemical Structure

Tamsulosin
Tamsulosin
CAS#106133-20-4 (free)

Theoretical Analysis

MedKoo Cat#: 318790

Name: Tamsulosin

CAS#: 106133-20-4 (free)

Chemical Formula: C20H28N2O5S

Exact Mass: 408.1719

Molecular Weight: 408.51

Elemental Analysis: C, 58.80; H, 6.91; N, 6.86; O, 19.58; S, 7.85

Price and Availability

Size Price Availability Quantity
10mg USD 250.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 850.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
106133-20-4 (free); 106463-17-6 (hydrochloride)
Synonym
HSDB-7744; HSDB7744; HSDB 7744; Tamsulosin; Flowmax; Harnal-D; (R)-tamsulosin; (R)-(-)-YM12617 free base; LY253351 free base
IUPAC/Chemical Name
(R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide
InChi Key
DRHKJLXJIQTDTD-OAHLLOKOSA-N
InChi Code
InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1
SMILES Code
O=S(C1=CC(C[C@H](NCCOC2=CC=CC=C2OCC)C)=CC=C1OC)(N)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 408.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Morones J, Pérez M, Muñoz M, Sánchez E, Ávila M, Topete J, Ventura J, Martínez S. Evaluation of the Effect of an α-Adrenergic Blocker, a PPAR-γ Receptor Agonist, and a Glycemic Regulator on Chronic Kidney Disease in Diabetic Rats. Int J Mol Sci. 2024 Oct 23;25(21):11372. doi: 10.3390/ijms252111372. PMID: 39518925; PMCID: PMC11545748. 2: Domínguez-Millán R, Pisciotti TL, Cuesta PF, Becerril MAB. Fowler syndrome post liposculpture and augmentation mammoplasty: Case report and literature review. JPRAS Open. 2024 Sep 26;42:292-295. doi: 10.1016/j.jpra.2024.09.013. PMID: 39498286; PMCID: PMC11532730. 3: Bumbuluț B, Stănilă DM. Floppy iris. How is floppy iris syndrome managed? What do urologists and ophthalmologists say? Rom J Ophthalmol. 2024 Jul- Sep;68(3):301-305. doi: 10.22336/rjo.2024.54. PMID: 39464767; PMCID: PMC11503239. 4: Ali SN, McCormac A, Cumpanas AD, Altamirano-Villarroel J, Piedras P, Vu MC, Afyouni AS, Tano ZE, Osann K, Klopfer M, Jiang P, Patel RM, Landman J, Clayman RV. Clinical determination of the natural distensibility of the human ureter: initial study. BJU Int. 2024 Oct 26. doi: 10.1111/bju.16564. Epub ahead of print. PMID: 39460553. 5: Abdulrasheed H, Adenipekun A, Mohsin MS, Khattak MA, Elsayed W, Cheema H, Dukic I. Audit of the Acute Management of Renal Colic in District Hospitals Within a National Health Service Trust. Cureus. 2024 Sep 20;16(9):e69825. doi: 10.7759/cureus.69825. PMID: 39435248; PMCID: PMC11491764. 6: Arnon R, Goldberg H, Ben-Simon GJ, Priel A, Zloto O, Landau-Prat D, Cukierman-Yaffe T, Agmon-Levin N, Sagiv O. Alpha-1 antagonist treatment for eyelid retraction in patients with thyroid eye disease-a prospective pilot study. Eye (Lond). 2024 Oct 21. doi: 10.1038/s41433-024-03403-8. Epub ahead of print. PMID: 39428445. 7: Kingsley R, Tyree S, Jarsania D, Edquist C, Palmer A, Gerberi D, Wilfahrt R, Pagali S. Association Between Alpha-1 Adrenoreceptor Antagonist Use and Cognitive Impairment: A Systematic Review. Int Neurourol J. 2024 Sep;28(3):171-180. doi: 10.5213/inj.2448266.133. Epub 2024 Sep 30. PMID: 39363407; PMCID: PMC11450241. 8: Kaushik J, Sharma R, Goyal S, Dangi M, Jha RK, Singh A. Alpha-adrenergic antagonists and iris dynamics: Challenges and solutions in cataract surgery. BMC Ophthalmol. 2024 Oct 3;24(1):431. doi: 10.1186/s12886-024-03705-1. PMID: 39363270; PMCID: PMC11451146. 9: Yang F, Hashim R, Philippou J. Tamsulosin and Dutasteride Combination Therapy for Asian Men With Moderate-to-Severe Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Systematic Review of Clinical Considerations That Influence the Prescription. J Clin Med Res. 2024 Sep;16(9):385-397. doi: 10.14740/jocmr5255. Epub 2024 Sep 12. PMID: 39346571; PMCID: PMC11426169. 10: Di Mauro E, Saldutto P, La Rocca R, Sangiorgi G, Patelli G, Barone B, Verratti V, Castellucci R, Napolitano L, Iacono F, Altieri VM. Efficacy and Safety of Boldine Combined with Phyllanthus niruri and Ononis spinosa in Medical Expulsive Therapy for Distal Ureteral Stones with Renal Colic: A Single-Center, Retrospective Cohort Study. Medicina (Kaunas). 2024 Sep 5;60(9):1455. doi: 10.3390/medicina60091455. PMID: 39336496; PMCID: PMC11434311. 11: Yuan XY, Li LX, Zhao Q, Zhang XY, Li Q, Zhao XF, Ji X. [Establishment and evaluation of haloalkane dehalogenase tagged α1A-adrenergic receptor chromatography]. Se Pu. 2024 Oct;42(10):935-942. Chinese. doi: 10.3724/SP.J.1123.2024.04026. PMID: 39327657; PMCID: PMC11439135. 12: Gupta S, Shyamsundar K, Pushkar K, Agrawal M, Mishra A, Tripathi A, Singh M. A randomized control study on post-operative iris distortion following small- pupil cataract surgery using B-HEX pupil expander versus Malyugin ring. Med J Armed Forces India. 2024 Sep-Oct;80(5):560-565. doi: 10.1016/j.mjafi.2024.05.001. Epub 2024 Jun 25. PMID: 39309579; PMCID: PMC11411337. 13: Fawzi HA, Akram SN, Talib AF, Alwan MH, Yasir LA. Comparing monotherapy with tadalafil or tamsulosin in men with benign prostatic hyperplasia: A case-control study. J Adv Pharm Technol Res. 2024 Jul-Sep;15(3):161-165. doi: 10.4103/JAPTR.JAPTR_87_24. Epub 2024 Jul 22. PMID: 39290552; PMCID: PMC11404432. 14: Takayama A, Yoshida S, Kawakami K. Tadalafil use is associated with a lower incidence of Type 2 diabetes in men with benign prostatic hyperplasia: A population-based cohort study. J Intern Med. 2024 Nov;296(5):422-434. doi: 10.1111/joim.20012. Epub 2024 Sep 17. PMID: 39287476. 15: Abbas A, Sathian B, Elawady M, Khan SHU, Abdalla AI, Hasabelgawy AHMA, Ghafouri AA, Osman SM, Hamad O Alzubier A, Idris OEA, Al Hamad H. Clinical features and management approaches for Urinary Incontinence in Older Adults: Evidence from Three Hospitals in Qatar. Nepal J Epidemiol. 2024 Sep 2;14(2):1333-1341. doi: 10.3126/nje.v14i2.69365. PMID: 39279992; PMCID: PMC11396563. 16: Zhang W, Jiang X, Jia Z, Tian H, Wang R, Ma Y, Ma Z, Wang X, Hu C. Drugs causing prostate-specific antigen changes: the food and drug administration adverse event reporting system combined with Mendelian randomization analysis. Expert Opin Drug Saf. 2024 Sep 18:1-8. doi: 10.1080/14740338.2024.2405577. Epub ahead of print. PMID: 39276000. 17: Gabra M, Hall C, McCann L, Shah J, Jones I, Masjedi A, Runke S, Hsu CH, Aguirre A. Tamsulosin and Time to Spontaneous Void After Hysterectomy: A Randomized Controlled Trial. Obstet Gynecol. 2024 Sep 12. doi: 10.1097/AOG.0000000000005724. Epub ahead of print. PMID: 39265173. 18: Horvath KU, Vultur F, Voidazan S, Simon V, Rusu AC. Intraoperative Iris Behavior during Phacoemulsification Maneuvers in Rabbits Treated with Selective α1-Blocker, 5α-Reductase Inhibitor, or Anxiolytic Medication. J Pers Med. 2024 Aug 9;14(8):840. doi: 10.3390/jpm14080840. PMID: 39202031; PMCID: PMC11355255. 19: Fung KW, Baye F, Baik SH, McDonald CJ. Tamsulosin use in benign prostatic hyperplasia and risks of Parkinson's disease, Alzheimer's disease and mortality: An observational cohort study of elderly Medicare enrollees. PLoS One. 2024 Aug 22;19(8):e0309222. doi: 10.1371/journal.pone.0309222. PMID: 39172922; PMCID: PMC11340942. 20: Brown N, Kiosoglous A, Castree S, Firouzmand S, McBean R, Walker DG, Wallace S, Kua B, Gianduzzo T, Esler RC, Campbell P, Schoeman J, Yaxley J. The 'Prostate Embolisation AS first-line therapY compAred to meDication in treatment naïVe men with prostAte eNlargement, a randomised ControllEd trial' (P-EASY ADVANCE): a randomised controlled trial of prostate embolisation vs medication for BPH. BJU Int. 2024 Aug 13. doi: 10.1111/bju.16479. Epub ahead of print. PMID: 39139009.

View History

Vif-A3G Inhibitor N.41

Vif-A3G Inhibitor N.41