MedKoo Cat#: 523117 | Name: MI-192
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MI-192 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC2 (IC50 = 30 nM) and HDAC3 (IC50 = 16 nM) over HDAC1, 4, 6, 7, and 8 (IC50s = 4.8, 5, >10, 4.1, and >10 μM, respectively).

Chemical Structure

MI-192
MI-192
CAS#1415340-63-4 (free base)

Theoretical Analysis

MedKoo Cat#: 523117

Name: MI-192

CAS#: 1415340-63-4 (free base)

Chemical Formula: C24H21N3O2

Exact Mass: 383.1634

Molecular Weight: 383.45

Elemental Analysis: C, 75.18; H, 5.52; N, 10.96; O, 8.34

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 750.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
MI-192; MI 192; MI192.
IUPAC/Chemical Name
N-(2-aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]-benzamide
InChi Key
GTLTXEIKQVWSRF-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H21N3O2/c1-16-14-27(24(29)20-7-3-2-6-19(16)20)15-17-10-12-18(13-11-17)23(28)26-22-9-5-4-8-21(22)25/h2-13H,1,14-15,25H2,(H,26,28)
SMILES Code
O=C(NC1=CC=CC=C1N)C2=CC=C(CN(CC(C3=C4C=CC=C3)=C)C4=O)C=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
Safety Data Sheet (SDS)

Preparing Stock Solutions

The following data is based on the product molecular weight 383.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bacon T, Seiler C, Wolny M, Hughes R, Watson P, Schwabe J, Grigg R, Peckham M. Histone deacetylase 3 indirectly modulates tubulin acetylation. Biochem J. 2015 Dec 15;472(3):367-77. doi: 10.1042/BJ20150660. Epub 2015 Oct 8. PubMed PMID: 26450925; PubMed Central PMCID: PMC4661566. 2: Boissinot M, Inman M, Hempshall A, James SR, Gill JH, Selby P, Bowen DT, Grigg R, Cockerill PN. Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk Res. 2012 Oct;36(10):1304-10. doi: 10.1016/j.leukres.2012.07.002. Epub 2012 Jul 20. PubMed PMID: 22818799.