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MedKoo Cat#: 523105 | Name: EML 425

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EML 425 is a reversible and non-competitive CBP/p300 inhibitor that is cell permeable (IC50 values are 1.1 and 2.9 μM, respectively).

Chemical Structure

EML 425
EML 425
CAS#1675821-32-5

Theoretical Analysis

MedKoo Cat#: 523105

Name: EML 425

CAS#: 1675821-32-5

Chemical Formula: C27H24N2O4

Exact Mass: 440.1736

Molecular Weight: 440.50

Elemental Analysis: C, 73.62; H, 5.49; N, 6.36; O, 14.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
EML 425; EML-425; EML425.
IUPAC/Chemical Name
5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
InChi Key
LUGQBJDYUPNAQQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H24N2O4/c1-18-13-22(30)14-19(2)23(18)15-24-25(31)28(16-20-9-5-3-6-10-20)27(33)29(26(24)32)17-21-11-7-4-8-12-21/h3-15,30H,16-17H2,1-2H3
SMILES Code
O=C1N(CC2=CC=CC=C2)C(/C(C(N1CC3=CC=CC=C3)=O)=C\C4=C(C)C=C(O)C=C4C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 440.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhou Z, Zhou B, Ren L, Meng Q. Effect of ensiled mulberry leaves and sun-dried mulberry fruit pomace on finishing steer growth performance, blood biochemical parameters, and carcass characteristics. PLoS One. 2014 Jan 10;9(1):e85406. doi: 10.1371/journal.pone.0085406. eCollection 2014. PubMed PMID: 24427304; PubMed Central PMCID: PMC3888424.