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MedKoo Cat#: 318770 | Name: Sulfametopyrazine
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulfametopyrazine is a long-acting sulfonamide antibacterial used for the treatment of chronic bronchitis, urinary tract infections and malaria.

Chemical Structure

Sulfametopyrazine
Sulfametopyrazine
CAS#152-47-6

Theoretical Analysis

MedKoo Cat#: 318770

Name: Sulfametopyrazine

CAS#: 152-47-6

Chemical Formula: C11H12N4O3S

Exact Mass: 280.0630

Molecular Weight: 280.30

Elemental Analysis: C, 47.14; H, 4.32; N, 19.99; O, 17.12; S, 11.44

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 weeks
10g USD 400.00 2 weeks
25g USD 750.00 2 weeks
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Related CAS #
No Data
Synonym
AS-18908; AS18908; AS 18908; Sulfametopyrazine; Sulfalen; Sulfalene;
IUPAC/Chemical Name
4-amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide
InChi Key
KXRZBTAEDBELFD-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15)
SMILES Code
COC1=NC=CN=C1NS(=O)(C2=CC=C(N)C=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 280.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Teo CP, Oh VM, Kueh YK. Agranulocytosis and anaemia induced by sulfametopyrazine in a sulfametopyrazine-trimethoprim combination. Ann Acad Med Singapore. 1989 May;18(3):307-10. PubMed PMID: 2549841. 2: Preza PC, Moura C, Leite Filho A, Cavallari V, Nüdemberg F, Piaia F. Distribution of trimethoprim and sulfametopyrazine in the female reproductive tract. J Int Med Res. 1986;14(2):101-4. PubMed PMID: 3699239. 3: Anderson G, Peel ET, Payne H, Ruth P. A single dose of sulfametopyrazine versus 7 days of ampicillin in acute on chronic bronchitis. Br J Dis Chest. 1985 Jul;79(3):258-61. PubMed PMID: 3893511. 4: Reeves DS, Bywater MJ, Bullock DW, Holt HA. Pharmacokinetic study of a sulfametopyrazine/trimethoprim combination (Kelfiprim) in human volunteers. J Antimicrob Chemother. 1980 Sep;6(5):647-56. PubMed PMID: 7410285. 5: Davies D, Darke CS. Sulfametopyrazine prophylaxis in chronic bronchitis. Br J Dis Chest. 1978 Jul;72(3):231-4. PubMed PMID: 359024. 6: Karim AK, Evans DA. Sulfametopyrazine metabolism in slow and rapid acetylators. Ann Trop Med Parasitol. 1976 Mar;70(1):123-4. PubMed PMID: 1267509. 7: Reeves DS. Laboratory and clinical studies with sulfametopyrazine as a treatment for bacteriuria in pregnancy. J Antimicrob Chemother. 1975 Jun;1(2):171-86. PubMed PMID: 1100589. 8: Picq JJ, Roux J, Charmot G, Lafaye A, Ricossé JH. [Duration of action of the pyrimethamine-sulfametopyrazine combination in a Plasmodium falciparum endemic zone]. Bull Soc Pathol Exot Filiales. 1975 Jan-Feb;68(1):61-7. French. PubMed PMID: 1100287. 9: Mahony JD, McCann JS, Harris JR, Howe JG, Dougan HJ. Oxytetracycline compared with single-dose therapy with sulfametopyrazine-streptomycin sulphate in nongonococcal urethritis in males. Br J Clin Pract. 1974 May;28(5):179-81. PubMed PMID: 4853517. 10: Medd RK, Burrows IE, Ross DB. Sulfametopyrazine: blood levels in neonatal piglets after a single oral dose. Vet Rec. 1973 Mar 10;92(10):263. PubMed PMID: 4714725. 11: Windsor BP, Langsdale GA, Hill J, Hooper WL, Allen HA. Sulfametopyrazine single-dose treatment of urinary tract infections n general practice. Br J Clin Pract. 1973 Jan;27(1):15-7. PubMed PMID: 4568133. 12: Darke CS, Weber JC, Beeley JM. Sulfametopyrazine in the prophylaxis of exacerbations of chronic bronchitis. Br J Dis Chest. 1972 Oct;66(4):276-83. PubMed PMID: 4563330. 13: Picq JJ, Charmot G, Ricosse JH. [Comparative study of a single dose of the pyrimethamine-sulfametopyrazine combination and chloroquine in the treatment of malaria attacks caused by Plasmodium falciparum in semi-immune patients in endemic areas (study carried out in Bobo-Dioulasso, Upper Volta)]. Med Trop (Mars). 1972 Jul-Aug;32(4):527-46. French. PubMed PMID: 4675015. 14: Mahony JD, Harris JR, Dougan HJ. Preliminary study of combined sulfametopyrazine and streptomycin single-dosage therapy in nongonococcal urethritis. Br J Clin Pract. 1972 Apr;26(4):173-4. PubMed PMID: 5036486. 15: Slade N, Crowther ST. Multicentre survey of urinary tract infections in general practice. Clinical trial of single dose treatment with sulfametopyrazine (Kelfizine-W). Br J Urol. 1972 Feb;44(1):105-9. PubMed PMID: 4556420. 16: Donno L, Catarinella G. Treatment of Plasmodium falciparum malaria in Cameroon with a single dose of antifolic drugs. 2. Combination of sulfametopyrazine and trimethoprim. J Trop Med Hyg. 1971 Nov;74(11):246-8. PubMed PMID: 4942347. 17: Catarinella G, Donno L. Treatment of Plasmodium falciparum malaria in Cameroon with a single dose of antifolic drugs. 1. Combination of sulfametopyrazine and pyrimethamine. J Trop Med Hyg. 1971 Nov;74(11):243-6. PubMed PMID: 4942346. 18: Williams JD, Smith EK. Single-dose therapy with streptomycin and sulfametopyrazine for bacteriuria during pregnancy. Br Med J. 1970 Dec 12;4(5736):651-3. PubMed PMID: 5488382; PubMed Central PMCID: PMC1820266. 19: Mazaud R, Roussilhon JP, Goube P, Scoffier JP, Bazillio R. [The sulfametopyrazine-pyrimethamine combination in the treatment of 100 P. falciparum malarial attacks]. Med Trop (Mars). 1970 Nov-Dec;30(6):759-66. French. PubMed PMID: 4928314. 20: Bonomo E, Castelfranco M, Chirico M, Cova N, Ferrari A, Franzini P, Girelli M, Nocca G, Pilotti A, Ratti G, Delmonte A, Scalvini A, Terruzzi L. [Polycentric clinical trials of new dosage regimens for sulfametopyrazine]. Minerva Med. 1970 Jul 14;61(56):3110-4. Italian. PubMed PMID: 5432047.