Synonym
Phenindione; 2-Phenyl-1,3-indandione; Phenylindanedione; Dindevan; Fenindion; Phenyline; Fenilin; Goldshield Brand of Phenindione; Merck Lipha Santé Brand of Phenindione;
IUPAC/Chemical Name
2-phenylindene-1,3-dione
InChi Key
NFBAXHOPROOJAW-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H
SMILES Code
C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
Phenindione is an anticoagulant which functions as a Vitamin K antagonist.
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| DMF |
30.0 |
134.99 |
|
| DMSO |
58.0 |
260.98 |
|
| DMSO:PBS (pH 7.2) (1:40) |
0.0 |
0.09 |
|
| Ethanol |
15.0 |
67.49 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
222.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sigalov MV. Keto-enol tautomerism of phenindione and its derivatives: an NMR
and density functional theory (DFT) reinvestigation. J Phys Chem A. 2015 Feb
26;119(8):1404-14. doi: 10.1021/jp512461c. Epub 2015 Feb 11. PubMed PMID:
25629727.
2: Natarajan B, Hart T, Smith S, Parry RG. Phenindione interference in enzymatic
creatinine assay - A case report. Clin Nephrol. 2015 Feb;83(2):121-3. doi:
10.5414/CN108108. PubMed PMID: 24361058.
3: Sankaralingam A, Karim Y, Swaminathan R. Phenindione interferes with
measurement of creatinine. Clin Biochem. 2013 Dec;46(18):1912-3. doi:
10.1016/j.clinbiochem.2013.08.017. Epub 2013 Sep 6. PubMed PMID: 24016729.
4: Gallus A, Nyfort-Hansen K. Transfer from phenindione to warfarin. Med J Aust.
1994 Sep 19;161(6):398. PubMed PMID: 8090126.
5: Cristau P, Merlin P, Larroque P, Roue R, Saliou P, Leleu JP. [Does chronic
hepatitis due to phenindione really exist?]. Med Chir Dig. 1980;9(8):725-6,
729-30. French. PubMed PMID: 7206870.
6: Gover PA, Ingram GI, Cork MS, Holland L, Hopkins RP, Callaghan P, Barkhan P,
Shearer MJ. Bleeding from self-administration of phenindione: a detailed case
study. Br J Haematol. 1976 Aug;33(4):551-64. PubMed PMID: 1009028.
7: Joram F, Le Bihan G, Bourreille J. [Acute nephropathy caused by phenindione
intolerance. Apropos of a recent case]. Sem Hop Ther. 1976 Jan;52(1):19-22.
French. PubMed PMID: 1257797.
8: Varma DR, Gupta RK, Gupta S. Prothrombin response to phenindione during
hypoalbuminaemia. Br J Clin Pharmacol. 1975 Oct;2(5):467-8. PubMed PMID: 1233073;
PubMed Central PMCID: PMC1402621.
9: Potier JC, Bories H, Foucault JP, Olivier J. [Letter: A new case of severe
intolerance to phenindione. Value of the lymphoblastic transformation test]. Nouv
Presse Med. 1975 Aug 30-Sep 6;4(28):2041. French. PubMed PMID: 1178450.
10: Gupta MC, Kumar S, Tyagi SP, Srivastava SS. Stomatitis, agranulocytosis and
hepatits due to phenindione sensitivity. J Indian Med Assoc. 1974 Nov
16;63(10):324-7. PubMed PMID: 4452787.
11: Khalil SH, Ali LM, Abdel-Khalek MM. Dissolution and disintegration
characteristics of some experimental formulations of phenindione tablets. 1.
Before storage. Pharmazie. 1973 Oct;28(10):659-61. PubMed PMID: 4783550.
12: Denson KW. The levels of factors II, VII, IX and X by antibody neutralization
techniques in the plasma of patients receiving phenindione therapy. Br J
Haematol. 1971 Jun;20(6):643-8. PubMed PMID: 5089955.
13: Lancaster-Smith MJ. Delayed reaction to phenindione. Lancet. 1969 Nov
8;2(7628):1011. PubMed PMID: 4186964.
14: Johnson DC, Reeve TS. The effects and clinical significance of heparin and
phenindione on a standard experimental femoral venous thrombus. Aust N Z J Surg.
1969 Nov;39(2):209-16. PubMed PMID: 5264528.
15: Kuschinsky G. [Severe side-effects in anticoagulant therapy using
phenindione]. Dtsch Med Wochenschr. 1969 May 9;94(19):1032. German. PubMed PMID:
5779804.
16: Manigand G, Auzépy P, Lardy C. [A case of serious intolerance during
treatment by phenindione: preventive measures to be taken]. Sem Hop. 1968 Dec
14;44(52):3217-22. French. PubMed PMID: 4307331.
17: Copeman PW. Side-effects of phenindione. Br Med J. 1968 Aug 31;3(5617):557.
PubMed PMID: 4234096; PubMed Central PMCID: PMC1986461.
18: Leigh J. Submucosal jejunal haemorrhage with phenindione. Australas Ann Med.
1967 Nov;16(4):330-2. PubMed PMID: 5299929.
19: Paliard P, Moulin G, Motin J, Robillard J, Perrot E. [Apropos of a case of a
therapeutic complication due to phenindione]. Lyon Med. 1967 Sep
10;217(37):389-93. French. PubMed PMID: 4247354.
20: Ganderton D, Hadgraft JW, Rispin WT, Thompson AG. The break-up and
dissolution of phenindione tablets. Pharm Acta Helv. 1967 Mar;42(3):152-62.
PubMed PMID: 5584478.
