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MedKoo Cat#: 318454 | Name: Paramethasone Acetate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Paramethasone Acetate is a fluorinated glucocorticoid with anti-inflammatory and immunosuppressant properties.

Chemical Structure

Paramethasone Acetate
Paramethasone Acetate
CAS#1597-82-6

Theoretical Analysis

MedKoo Cat#: 318454

Name: Paramethasone Acetate

CAS#: 1597-82-6

Chemical Formula: C24H31FO6

Exact Mass: 0.0000

Molecular Weight: 434.50

Elemental Analysis: C, 66.34; H, 7.19; F, 4.37; O, 22.09

Price and Availability

Size Price Availability Quantity
5mg USD 550.00
50mg USD 1,700.00 2 Weeks
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Related CAS #
No Data
Synonym
Paramethasone Acetate; UNII-8X50N88ZDP; Monocortin; 8X50N88ZDP; CHEBI:31963; NCGC00185748-01; Haldrone (TN);
IUPAC/Chemical Name
16-alpha-Methyl-6-alpha-fluoro-prednisolone-21-acetate
InChi Key
HYRKAAMZBDSJFJ-WMCOPNSBSA-N
InChi Code
InChI=1S/C24H31FO6/c1-12-7-16-15-9-18(25)17-8-14(27)5-6-22(17,3)21(15)19(28)10-23(16,4)24(12,30)20(29)11-31-13(2)26/h5-6,8,12,15-16,18-19,21,28,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19?,21-,22+,23+,24+/m1/s1
SMILES Code
CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1(C(=O)COC(=O)C)O)C)O)C)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Paramethasone acetate is a synthetic glucocorticoid, and shows anti-inflammatory and immunosuppressant activities.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 434.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Lo K, Liman AN, Zhang Y, Ye W. Tongue coating metabolic profiles of intra- oral halitosis patients. Oral Dis. 2024 Jun 9. doi: 10.1111/odi.15034. Epub ahead of print. PMID: 38852162. 2: Liman AN, Zhu HL, Yang WJ, Ye W. [Metabolomics study on the difference of tongue coating metabolites between patients with intra-oral halitosis and healthy individual]. Shanghai Kou Qiang Yi Xue. 2023 Oct;32(5):525-531. Chinese. PMID: 38171524. 3: Ferrando J, Moreno-Arias GA. Multi-injection plate for intralesional corticosteroid treatment of patchy alopecia areata. Dermatol Surg. 2000 Jul;26(7):690-1. doi: 10.1046/j.1524-4725.2000.00002.x. PMID: 10886282. 4: Miranda-Romero A, Bajo-del Pozo C, Sánchez-Sambucety P, Martinez-Fernandez M, Garcia-Muñoz M. Delayed local allergic reaction to intralesional paramethasone acetate. Contact Dermatitis. 1998 Jul;39(1):31-2. doi: 10.1111/j.1600-0536.1998.tb05810.x. PMID: 9686977. 5: Gonzalo Garijo MA, Durán Quintana JA, Bobadilla González P, Máiquez Asuero P. Anaphylactic shock following povidone. Ann Pharmacother. 1996 Jan;30(1):37-40. doi: 10.1177/106002809603000107. PMID: 8773164. 6: Taniguchi Y, Sakamoto T, Shimizu M. A case of necrobiosis lipoidica treated with systemic corticosteroid. J Dermatol. 1993 May;20(5):304-7. doi: 10.1111/j.1346-8138.1993.tb01396.x. PMID: 8340536. 7: Pisonero P, Vallejo L, Menéndez E, Evangelista CR, Alonso A. Treatment for facial neuronitis: a new approach to Bell's palsy. An Otorrinolaringol Ibero Am. 1991;18(4):361-74. PMID: 1716859. 8: Schultz RM, Howbert JJ, Archer RA. Potent inhibition of interleukin 1 beta- mediated human melanoma (A375.6) lysis by corticosteroids, staurosporine, and tilorone. Immunopharmacol Immunotoxicol. 1989;11(2-3):489-506. doi: 10.3109/08923978909005380. PMID: 2621325. 9: Cortés-Gallegos V, Alonso R, Castañeda G, Sojo I, Carranco A, Cervantes C, Parra A. Paramethasone acetate (PA): corticosteroid potency vs hypothalamic pituitary-gonadal axis. J Steroid Biochem. 1984 Jan;20(1):353-6. doi: 10.1016/0022-4731(84)90232-2. PMID: 6423900. 10: Colombo C, Butler M, Hickman L, Selwyn M, Chart J, Steinetz B. A new model of osteoarthritis in rabbits. II. Evaluation of anti-osteoarthritic effects of selected antirheumatic drugs administered systemically. Arthritis Rheum. 1983 Sep;26(9):1132-9. doi: 10.1002/art.1780260911. PMID: 6688529. 11: Cortés-Gallegos V, Carranco A, Sojo I, Alonso R, Valenzuela-Duriet P. Effect of paramethasone acetate upon estrogen action. Fertil Steril. 1982 Mar;37(3):402-5. PMID: 7060790. 12: Fuentes, Vigaray. Estudio de la eficacia de una preparación inyectable de fosfato y acetato de parametasona en la rinitis alérgica estacional [Efficacy of an injectable preparation of paramethasone acetate and phosphate in seasonal allergic rhinitis]. Allergol Immunopathol (Madr). 1981 Mar-Apr;9(2):153-4. Spanish. PMID: 7293877. 13: Derelanko MJ, Long JF. Effect of corticosteroids on indomethacin-induced intestinal ulceration in the rat. Dig Dis Sci. 1980 Nov;25(11):823-9. doi: 10.1007/BF01338523. PMID: 7438955. 14: Saito Z, Amatsu E, Ono T, Hihumi S, Mimou T, Hashiba T, Sakato S, Miyamoto M, Takeda R. [The high pressure liquid chromatography of corticoids. II. Analysis of synthetic corticoids in blood and urine (author's transl)]. Nihon Naibunpi Gakkai Zasshi. 1979 Oct 20;55(10):1296-306. Japanese. doi: 10.1507/endocrine1927.55.10_1296. PMID: 510630. 15: Cortés-Gallegos V, Alonso-Uriarte ME, Said LE, Cervantes C, Parra A. Effect of paramethasone acetate on women with secondary amenorrhea: a preliminary report. Fertil Steril. 1978 Apr;29(4):402-6. doi: 10.1016/s0015-0282(16)43213-9. PMID: 77230. 16: Boris A, Hurley JF. Assessment of topical anti-inflammatory activity in rats with cantharidin-induced inflammation. J Invest Dermatol. 1977 Mar;68(3):161-4. doi: 10.1111/1523-1747.ep12492482. PMID: 839089. 17: Montes Eeyes JS. Tratamiento de las lesiones deportivas mediante el acetato de parametasona [Treatment of sport injuries by using paramethasone acetate]. Rev Esp Reum Enferm Osteoartic. 1976;19(2):203-24. Spanish. PMID: 959639. 18: Cortés-Gallegos V, Gallegos AJ, Tovar NB, Cervantes C, Parra A. Effect of paramethasone acetate on ovarian steroids and gonadotropins. I. Normal menstrual cycle. J Clin Endocrinol Metab. 1975 Aug;41(2):215-20. doi: 10.1210/jcem-41-2-215. PMID: 1159039. 19: Badia Flores JJ, Valdez Rojas S. Naproxen: corticosteroid-sparing effect in rheumatoid arthritis. J Clin Pharmacol. 1975 Apr;15(4 Pt. 2):373-7. doi: 10.1002/j.1552-4604.1975.tb01467.x. PMID: 1092731. 20: Toribio JT, Quicres PA. Inflammatory linear verrucose epidermal nevus. Dermatologica. 1975;150(2):65-9. doi: 10.1159/000251404. PMID: 1158005.

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