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MedKoo Cat#: 317632 | Name: Dofetilide
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dofetilide is a Class III antiarrhythmic agent used primarily to maintain sinus rhythm in patients with atrial fibrillation or flutter. It exerts its effect by selectively blocking the rapid component of the delayed rectifier potassium current (IK<sub>r</sub>) in cardiac myocytes, thereby prolonging action potential duration and refractoriness. Clinically, dofetilide’s bioactivity manifests as QT interval prolongation on the ECG, reducing the likelihood of recurrent atrial arrhythmias when dosed and monitored carefully.

Chemical Structure

Dofetilide
Dofetilide
CAS#115256-11-6

Theoretical Analysis

MedKoo Cat#: 317632

Name: Dofetilide

CAS#: 115256-11-6

Chemical Formula: C19H27N3O5S2

Exact Mass: 441.1392

Molecular Weight: 441.56

Elemental Analysis: C, 51.68; H, 6.16; N, 9.52; O, 18.12; S, 14.52

Price and Availability

Size Price Availability Quantity
10mg USD 250.00 2 Weeks
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Dofetilide; Dofetilidum; Tikosyn; Dofetilida; UK 68798; UK68798; UK-68798;
IUPAC/Chemical Name
N-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide
InChi Key
IXTMWRCNAAVVAI-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
SMILES Code
CS(=O)(NC1=CC=C(OCCN(CCC2=CC=C(NS(=O)(C)=O)C=C2)C)C=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 441.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shenasa F, Shenasa M. Dofetilide: Electrophysiologic Effect, Efficacy, and Safety in Patients with Cardiac Arrhythmias. Card Electrophysiol Clin. 2016 Jun;8(2):423-36. doi: 10.1016/j.ccep.2016.02.006. Epub 2016 Mar 23. PMID: 27261832. 2: Uddin ME, Eisenmann ED, Li Y, Huang KM, Garrison DA, Talebi Z, Gibson AA, Jin Y, Nepal M, Bonilla IM, Fu Q, Sun X, Millar A, Tarasov M, Jay CE, Cui X, Einolf HJ, Pelis RM, Smith SA, Radwański PB, Sweet DH, König J, Fromm MF, Carnes CA, Hu S, Sparreboom A. MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia. Int J Mol Sci. 2022 Aug 3;23(15):8607. doi: 10.3390/ijms23158607. PMID: 35955741; PMCID: PMC9369325. 3: Mounsey JP, DiMarco JP. Cardiovascular drugs. Dofetilide. Circulation. 2000 Nov 21;102(21):2665-70. doi: 10.1161/01.cir.102.21.2665. PMID: 11085972. 4: McClellan KJ, Markham A. Dofetilide: a review of its use in atrial fibrillation and atrial flutter. Drugs. 1999 Dec;58(6):1043-59. doi: 10.2165/00003495-199958060-00007. PMID: 10651390. 5: Moore JC, Trager L, Anzia LE, Saliba W, Bassiouny M, Bhargava M, Chung M, Desai M, Garberich R, Lever H, Lindsay BD, Sengupta J, Tchou P, Wazni O, Wilkoff BL. Dofetilide for suppression of atrial fibrillation in hypertrophic cardiomyopathy: A case series and literature review. Pacing Clin Electrophysiol. 2018 Apr;41(4):396-401. doi: 10.1111/pace.13310. Epub 2018 Mar 12. PMID: 29450893. 6: Kalus JS, Mauro VF. Dofetilide: a class III-specific antiarrhythmic agent. Ann Pharmacother. 2000 Jan;34(1):44-56. doi: 10.1345/aph.19185. PMID: 10669186. 7: Jaiswal A, Goldbarg S. Dofetilide induced torsade de pointes: mechanism, risk factors and management strategies. Indian Heart J. 2014 Nov-Dec;66(6):640-8. doi: 10.1016/j.ihj.2013.12.021. Epub 2014 Jan 7. PMID: 25634399; PMCID: PMC4311014. 8: Subedi R, Dean RK, Dhamoon AS. Dofetilide-Induced Severe Hepatotoxicity. Am J Ther. 2018 Nov/Dec;25(6):e783-e784. doi: 10.1097/MJT.0000000000000793. PMID: 29912716. 9: Torp-Pedersen C, Moller M, Kober L, Camm AJ. Dofetilide for the treatment of atrial fibrillation in patients with congestive heart failure. Eur Heart J. 2000 Aug;21(15):1204-6. doi: 10.1053/euhj.1999.2049. PMID: 10924306. 10: Marcantoni I, Laratta R, Mascia G, Ricciardi L, Sbrollini A, Nasim A, Morettini M, Burattini L. Dofetilide-Induced Microvolt T-Wave Alternans. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:95-98. doi: 10.1109/EMBC.2019.8857486. PMID: 31945853. 11: Torp-Pedersen C, Brendorp B, Køber L. Dofetilide: a class III anti- arrhythmic drug for the treatment of atrial fibrillation. Expert Opin Investig Drugs. 2000 Nov;9(11):2695-704. doi: 10.1517/13543784.9.11.2695. PMID: 11060831. 12: Song JC, White CM. Dofetilide (Tikosyn). Conn Med. 2000 Oct;64(10):601-4. PMID: 11100632. 13: Roukoz H, Saliba W. Dofetilide: a new class III antiarrhythmic agent. Expert Rev Cardiovasc Ther. 2007 Jan;5(1):9-19. doi: 10.1586/14779072.5.1.9. PMID: 17187453. 14: Falk RH, Decara JM. Dofetilide: a new pure class III antiarrhythmic agent. Am Heart J. 2000 Nov;140(5):697-706. doi: 10.1067/mhj.2000.110457. PMID: 11054613. 15: Al-Dashti R, Sami M. Dofetilide: a new class III antiarrhythmic agent. Can J Cardiol. 2001 Jan;17(1):63-7. PMID: 11173316. 16: Briceño DF, Supple GE. Dofetilide Reloaded: To Admit or Not to Admit, That is the Question. Circ Arrhythm Electrophysiol. 2017 Oct;10(10):e005815. doi: 10.1161/CIRCEP.117.005815. PMID: 29038110. 17: Saliba WI. Dofetilide (Tikosyn): a new drug to control atrial fibrillation. Cleve Clin J Med. 2001 Apr;68(4):353-63. doi: 10.3949/ccjm.68.4.353. PMID: 11326815. 18: Lenz TL, Hilleman DE. Dofetilide, a new class III antiarrhythmic agent. Pharmacotherapy. 2000 Jul;20(7):776-86. doi: 10.1592/phco.20.9.776.35208. PMID: 10907968. 19: Olshansky B. Dofetilide versus quinidine for atrial flutter: viva la difference!? J Cardiovasc Electrophysiol. 1996 Sep;7(9):828-32. doi: 10.1111/j.1540-8167.1996.tb00595.x. PMID: 8884511. 20: Elming H, Brendorp B, Pedersen OD, Køber L, Torp-Petersen C. Dofetilide: a new drug to control cardiac arrhythmia. Expert Opin Pharmacother. 2003 Jun;4(6):973-85. doi: 10.1517/14656566.4.6.973. PMID: 12783593.