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MedKoo Cat#: 522667 | Name: SNAP-8719

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SNAP-8719 is a selective α1D-AR antagonist. SNAP-8719 showed better selectivity for α1D-AR, with lower binding affinity for the 5-HT1A receptor.

Chemical Structure

SNAP-8719
SNAP-8719
CAS#255893-38-0

Theoretical Analysis

MedKoo Cat#: 522667

Name: SNAP-8719

CAS#: 255893-38-0

Chemical Formula: C22H29ClF3N3O2

Exact Mass:

Molecular Weight: 459.94

Elemental Analysis: C, 57.45; H, 6.36; Cl, 7.71; F, 12.39; N, 9.14; O, 6.96

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SNAP-8719; SNAP 8719; SNAP8719.
IUPAC/Chemical Name
(R)-8-(1-(4-(2,4,5-trifluorophenyl)piperazin-1-yl)propan-2-yl)-8-azaspiro[4.5]decane-7,9-dione hydrochloride
InChi Key
RCZNKGIWVMAQHC-XFULWGLBSA-N
InChi Code
InChI=1S/C22H28F3N3O2.ClH/c1-15(28-20(29)12-22(13-21(28)30)4-2-3-5-22)14-26-6-8-27(9-7-26)19-11-17(24)16(23)10-18(19)25;/h10-11,15H,2-9,12-14H2,1H3;1H/t15-;/m1./s1
SMILES Code
Cl[H].O=C(N(C(C1)=O)[C@H](C)CN2CCN(CC2)C3=CC(F)=C(F)C=C3F)CC41CCCC4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 459.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sakauchi N, Kohara Y, Sato A, Suzaki T, Imai Y, Okabe Y, Imai S, Saikawa R, Nagabukuro H, Kuno H, Fujita H, Kamo I, Yoshida M. Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carb oxamide (TAK-259), as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Anti-urinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities. J Med Chem. 2016 Mar 8. [Epub ahead of print] PubMed PMID: 26954848.

View History

SNIPER(ABL)-38

SNIPER(ABL)-38