Synonym
TUG-770; TUG 770; TUG770.
IUPAC/Chemical Name
3-[4-[2-[2-(cyanomethyl)phenyl]ethynyl]-2-fluorophenyl]propanoic acid
InChi Key
KIZUBVPJNPVIIN-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H14FNO2/c20-18-13-14(6-8-17(18)9-10-19(22)23)5-7-15-3-1-2-4-16(15)11-12-21/h1-4,6,8,13H,9-11H2,(H,22,23)
SMILES Code
O=C(O)CCC1=CC=C(C#CC2=CC=CC=C2CC#N)C=C1F
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
307.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Takai M, Yamamoto M, Yashiro N, Tamura M, Taniguchi A, Nagano S, Kusumoto Y, Tsujiuchi T. FFAR-mediated signaling drives migration of pancreatic cancer cells in hypoxic fibroblast co-cultures. Biochem Biophys Res Commun. 2024 Oct 1;727:150322. doi: 10.1016/j.bbrc.2024.150322. Epub 2024 Jun 27. PMID: 38945064.
2: Yashiro N, Takai M, Yamamoto M, Amano Y, Hara K, Tsujiuchi T. Effects of free fatty acid receptor (FFAR) signaling on the modulation of cancer cell functions under hypoxic conditions. Biochem Biophys Res Commun. 2024 Mar 5;699:149554. doi: 10.1016/j.bbrc.2024.149554. Epub 2024 Jan 24. PMID: 38280308.
3: Minami K, Ueda N, Ishimoto K, Tsujiuchi T. Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells. J Recept Signal Transduct Res. 2020 Apr;40(2):181-186. doi: 10.1080/10799893.2020.1725047. Epub 2020 Feb 6. PMID: 32026734.
4: Urano Y, Oda S, Tsuneyama K, Yokoi T. Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice. Chem Biol Interact. 2018 Dec 25;296:185-197. doi: 10.1016/j.cbi.2018.09.011. Epub 2018 Sep 20. PMID: 30243991.
5: Christiansen E, Hansen SV, Urban C, Hudson BD, Wargent ET, Grundmann M, Jenkins L, Zaibi M, Stocker CJ, Ullrich S, Kostenis E, Kassack MU, Milligan G, Cawthorne MA, Ulven T. Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2013 May 9;4(5):441-445. doi: 10.1021/ml4000673. Epub 2013 Apr 8. PMID: 23687558; PMCID: PMC3654565.
