NCC-149 | CAS#1316652-41-1 | HDAC8 inhibitor

MedKoo Cat#: 407293 | Name: NCC-149

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NCC-149 is a HDAC8 inhibitor.

Chemical Structure

NCC-149

CAS#1316652-41-1

Theoretical Analysis

MedKoo Cat#: 407293

Name: NCC-149

CAS#: 1316652-41-1

Chemical Formula: C16H14N4O2S

Exact Mass: 326.0837

Molecular Weight: 326.37

Elemental Analysis: C, 58.88; H, 4.32; N, 17.17; O, 9.80; S, 9.82

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 650.00	2 Weeks

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Related CAS #

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Synonym

NCC-149; NCC 149; NCC149.

IUPAC/Chemical Name

N-hydroxy-3-(1-((phenylthio)methyl)-1H-1,2,3-triazol-4-yl)benzamide

InChi Key

DORPIZJGSLWDIY-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H14N4O2S/c21-16(18-22)13-6-4-5-12(9-13)15-10-20(19-17-15)11-23-14-7-2-1-3-8-14/h1-10,22H,11H2,(H,18,21)

SMILES Code

O=C(NO)C1=CC=CC(C2=CN(CSC3=CC=CC=C3)N=N2)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO, not in water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot# T21C11I01

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

NCC-149 is a HDAC8 inhibitor.

In vitro activity:

HDAC8-selective inhibitor (NCC-149) (HDAC8i)-treated cells showed smaller EBs than non-treated cells, as well as reduced expression levels of the neuronal marker, NeuN. Reference: Biochem Biophys Res Commun. 2018 Mar 25;498(1):45-51. https://pubmed.ncbi.nlm.nih.gov/29499194/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 326.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Katayama S, Morii A, Makanga JO, Suzuki T, Miyata N, Inazu T. HDAC8 regulates neural differentiation through embryoid body formation in P19 cells. Biochem Biophys Res Commun. 2018 Mar 25;498(1):45-51. doi: 10.1016/j.bbrc.2018.02.195. Epub 2018 Feb 28. PMID: 29499194.

In vitro protocol:

In vivo protocol:

TBD

1. Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors. By Tang, Guozhi; Wong, Jason C.; Zhang, Weixing; Wang, Zhanguo; Zhang, Nan; Peng, Zhenghong; Zhang, Zhenshan; Rong, Yiping; Li, Shijie; Zhang, Meifang; et al. From Journal of Medicinal Chemistry (2014), 57(19), 8026-8034. 2. Design, Synthesis, and Biological Activity of NCC149 Derivatives as Histone Deacetylase 8-Selective Inhibitors. By Suzuki, Takayoshi; Muto, Nobusuke; Bando, Masashige; Itoh, Yukihiro; Masaki, Ayako; Ri, Masaki; Ota, Yosuke; Nakagawa, Hidehiko; Iida, Shinsuke; Shirahige, Katsuhiko; et al. From ChemMedChem (2014), 9(3), 657-664. 3. Rapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries. Suzuki, Takayoshi; Ota, Yosuke; Ri, Masaki; Bando, Masashige; Gotoh, Aogu; Itoh, Yukihiro; Tsumoto, Hiroki; Tatum, Prima R.; Mizukami, Tamio; Nakagawa, Hidehiko; et al. From Journal of Medicinal Chemistry (2012), 55(22), 9562-9575. 4. Preparation of hydroxamic acid derivatives as HDAC8 inhibitors. By Miyata, Naoki; Suzuki, Takayoshi; Ota, Yosuke; Ueda, Ryuzo; Iida, Shinsuke; Ri, Masaki. From PCT Int. Appl. (2011), WO 2011089995 A1 20110728.