MedKoo Cat#: 317982 | Name: Guanadrel Sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Guanadrel Sulfate is a postganglionic adrenergic blocking agent. The uptake of guanadrel and storage in sympathetic neurons occurs via the norepinephrine pump or transporter.

Chemical Structure

Guanadrel Sulfate
Guanadrel Sulfate
CAS#22195-34-2

Theoretical Analysis

MedKoo Cat#: 317982

Name: Guanadrel Sulfate

CAS#: 22195-34-2

Chemical Formula: C10H21N3O6S

Exact Mass: 311.1151

Molecular Weight: 311.36

Elemental Analysis: C, 38.58; H, 6.80; N, 13.50; O, 30.83; S, 10.30

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Guanadrel Sulfate; Hylorel; Hyloride; CL 1388R; U 28288D; CHEBI:5556; Hylorel;
IUPAC/Chemical Name
2-(1,4-dioxaspiro[4.5]decan-3-ylmethyl)guanidine;sulfuric acid
InChi Key
RTEVGQJRTFFMLL-UHFFFAOYSA-N
InChi Code
InChI=1S/2C10H19N3O2.H2O4S/c2*11-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10;1-5(2,3)4/h2*8H,1-7H2,(H4,11,12,13);(H2,1,2,3,4)
SMILES Code
C1CCC2(CC1)OCC(O2)CN=C(N)N.C1CCC2(CC1)OCC(O2)CN=C(N)N.OS(=O)(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 311.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Darga LL, Hakim MJ, Lucas CP, Franklin BA. Comparison of the effects of guanadrel sulfate and propranolol on blood pressure, functional capacity, serum lipoproteins and glucose in systemic hypertension. Am J Cardiol. 1991 Mar 15;67(7):590-6. PubMed PMID: 2000792. 2: Sekkarie MA, Egan BM, Neubig RR, Supiano MA. Sensitization of human alpha 1- and alpha 2-adrenergic venous responses by guanadrel sulfate. Clin Pharmacol Ther. 1990 Nov;48(5):537-43. PubMed PMID: 2171846. 3: Palmer JD, Nugent CA. Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy. 1983 Jul-Aug;3(4):220-9. PubMed PMID: 6351026. 4: Nugent CA, Palmer JD, Ursprung JJ. Guanadrel sulfate compared with methyldopa for mild and moderate hypertension. Pharmacotherapy. 1982 Nov-Dec;2(6):378-83. PubMed PMID: 6762533. 5: Cangiano JL, Bloomfield DK. Hemodynamic effects of a new antihypertensive agent, guanadrel sulfate. Curr Ther Res Clin Exp. 1969 Dec;11(12):736-44. PubMed PMID: 4984037. 6: Bloomfield DK, Cangiano JL. Clinical experience with a new antihypertensive agent, guanadrel sulfate. Curr Ther Res Clin Exp. 1969 Dec;11(12):727-35. PubMed PMID: 4984036.